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製品番号: HY-114015

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APC-6860

APC-6860 is a competitive, selective arylamidine Serine protease inhibitor, with a K_i of 0.44 μM for trypsin, 0.10 μM for h-uPA, and 0.082 μM for mouse uPA. APC-6860 inhibits urokinase-activated plasminogen-mediated degradation of Fibronectin in cancer cells. APC-6860 is applicable to research related to breast cancer and prostate cancer.

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CAS 番号: 154628-42-9
分子式: C₉H₇IN₂S
分子量:302.13

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

APC-6860 構造式

CAS 番号: 154628-42-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

APC-6860 potently and competitively inhibits uPA with a K_i value of 0.21 µM. It exhibits low inhibitory activity against trypsin-like serine proteases including trypsin, tryptase, tPA, thrombin and factor Xa, and shows 80-fold higher selectivity for uPA over tPA^[1].
APC-6860 (Compound 2) (0.01-250 μM) exhibits inhibitory activity against h-urokinase, with a K_i value of 0.10 μM^[2].
APC-6860 (0.01-250 μM) inhibits recombinant murine urokinase, with a K_i value of 0.082 μM^[2].
APC-6860 (serial dilution; 2.5 h) inhibits urokinase-mediated fibronectin degradation in MiaPaCa-2 pancreatic cancer cells with an IC₅₀ of 1.4 μM^[2].
APC-6860 (serial dilution; 2.5 h) inhibits urokinase-mediated fibronectin degradation in mouse Lewis lung cancer cells, with an IC₅₀ of 3.1 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Breast Cancer Modeling

化学情報

CAS 番号 154628-42-9
分子量 302.13
分子式 C₉H₇IN₂S
SMILES

N=C(C1=CC2=C(I)C=CC=C2S1)N
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312. [Content Brief]

[2]. Klinghofer V, et al. Species specificity of amidine-based urokinase inhibitors. Biochemistry. 2001;40(31):9125-9131. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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