Apoptosis inducer 46
Apoptosis inducer 46 is an apoptosis inducer. Apoptosis inducer 46 exhibits potent and selective growth inhibitory effects on metastatic triple-negative breast cancer (TNBC) cells. Apoptosis inducer 46 induces G2/M phase cell cycle arrest and apoptotic cell death in MDA-MB-231 cells, and blocks NF-κB nuclear translocation. Apoptosis inducer 46 can be used for the study of TNBC.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3085356-41-5
- 分子式: C24H25NO3
- 分子量:375.46
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
Apoptosis inducer 46 (Compound 5d) (96 h) exhibits potent growth inhibitory effects on metastatic triple-negative breast cancer (TNBC) MDA-MB-231, HCC 1806, MCF-7, BEAS 2B cells with IC50s of 0.38 μM, 0.31 μM, 0.39 μM, 0.7 μM, respectively[1].
Apoptosis inducer 46 (5-40 μM, 2-4 h) significantly reduces proteasome activity in MDA-MB-231 cells with an IC50 of 37.0 μM for proteasome inhibition, and induces accumulation of ubiquitinated proteins[1].
Apoptosis inducer 46 (5 μM, 24-72 h) increases the apoptosis rate and causes progressive accumulation of MDA-MB-231 cells in the G2/M phase of the cell cycle[1].
Apoptosis inducer 46 (5-20 μM) stabilizes cyclin D1, p53, and p21 proteins, prevents degradation of IκBα, IκBε, and IκKγ, and inhibits nuclear translocation of NF-κB in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MDA-MB-231 cells
-
Concentration:5 μM
-
Incubation Time:24, 48, 72 h
-
Result:Increased the apoptosis rate of MDA-MB-231 cells.
-
Cell Line:MDA-MB-231 cells
-
Concentration:5 μM
-
Incubation Time:24, 48, 72 h
-
Result:Caused progressive accumulation of MDA-MB-231 cells in the G2/M phase of the cell cycle.
化学情報
-
CAS 番号 3085356-41-5
-
分子量 375.46
-
分子式 C24H25NO3
-
SMILES
OC1=C(C=C(C=C1)/C=C2CN(C3CC3)C/C(C\2=O)=C\C4=CC=C(C=C4)C)OC
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Apoptosis inducer 46 関連分類
HY-178132 関連分類
Powered by Bioz