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製品番号: HY-135743

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Apovincamine

Name: Apovincamine
Brand: MedChemExpress
SKU: HY-135743
Price: 298.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(別名: cis-Apovincamine; (+)-Apovincamine)

Apovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity.

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CAS 番号: 4880-92-6
分子式: C₂₁H₂₄N₂O₂
分子量:336.43

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Apovincamine 構造式

CAS 番号: 4880-92-6

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Apovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
B16	IC₅₀	49.8 μM Compound: apovincamine	Antimelanogenic activity in mouse B16 cells assessed as decrease in intracellular melanin level after 4 days Antimelanogenic activity in mouse B16 cells assessed as decrease in intracellular melanin level after 4 days	[PMID: 20576577]
INS1(832/13)	EC₅₀	5.03 μM Compound: Vin-A01	Cytoprotective activity in rat INS-1 832/13 cells assessed as inhibition of STZ-induced apoptosis incubated for 24 hrs by MTT assay Cytoprotective activity in rat INS-1 832/13 cells assessed as inhibition of STZ-induced apoptosis incubated for 24 hrs by MTT assay	[PMID: 31918073]

体外実験

Apovincamine (cis-Apovincamine; 6.3, 12.5, 25, 50, 100 μM) dose-dependently inhibits cells viability with an IC₅₀ of 49.8 μM and shows anti-melanogenesis in B16 mouse melanoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

化学情報

CAS 番号 4880-92-6
分子量 336.43
分子式 C₂₁H₂₄N₂O₂
SMILES

[H][C@]12[C@]3(CC)C=C(C(OC)=O)N(C4=CC=CC=C45)C1=C5CCN2CCC3
別名

cis-Apovincamine; (+)-Apovincamine
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Koichiro Koyama, et al. Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophore. Bioorg Med Chem. 2010 Jun 15;18(12):4415-21. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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