(aS)-PH-797804
Based on 7 publication(s) in Google Scholar
(aS)-PH-797804 is a selective p38 MAPK inhibitor with IC50 values for p38 α /β of 26 nM and 102 nM, respectively. (aS)-PH-797804 has anti-inflammatory activity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1358027-80-1
- 分子式: C22H19BrF2N2O3
- 分子量:477.30
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 (aS)-PH-797804
More- Sci Transl Med. 2018 Jul 18;10(450):eaaq1093. [Abstract]
- Cell Death Dis. 2021 Oct 23;12(11):994. [Abstract]
- Cell Death Dis. 2018 Apr 27;9(5):500. [Abstract]
- Osteoarthritis Cartilage. 2022 Aug;30(8):1140-1153. [Abstract]
- J Pharmacol Exp Ther. 2019 Aug;370(2):219-230. [Abstract]
- Oral Dis. 2025 Oct 27. [Abstract]
- bioRxiv. 2023 Feb 8.
生物活性
|
p38α 26 nM (IC50) |
p38β 102 nM (IC50) |
化学情報
-
CAS 番号 1358027-80-1
-
分子量 477.30
-
分子式 C22H19BrF2N2O3
-
SMILES
O=C(NC)C1=CC(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C(C)C=C1.[(aS)-PH-797804]
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (7)
-
Journal Impact Factor
-
Most Recent
-
Sci Transl Med
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. [Abstract]2018 Jul 18;10(450):eaaq1093. PMID: 30021885 -
Cell Death Dis
Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine production. [Abstract]2021 Oct 23;12(11):994. PMID: 34689152 -
Cell Death Dis
Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression. [Abstract]2018 Apr 27;9(5):500. PMID: 29703889 -
Osteoarthritis Cartilage
Chondrocyte apoptosis in temporomandibular joint osteoarthritis promotes bone resorption by enhancing chemotaxis of osteoclast precursors. [Abstract]2022 Aug;30(8):1140-1153. PMID: 35513247 -
J Pharmacol Exp Ther
Clinically Advanced p38 Inhibitors Suppress DUX4 Expression in Cellular and Animal Models of Facioscapulohumeral Muscular Dystrophy. [Abstract]2019 Aug;370(2):219-230. PMID: 31189728 -
Oral Dis
2025 Oct 27. PMID: 41146398 -
純度とドキュメンテーション
参考文献
[1]. Hope HR, et al. Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation. J Pharmacol Exp Ther. 2009 Dec;331(3):882-95. [Content Brief]
[2]. Selness SR, et al. Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4066-71. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
(aS)-PH-797804 関連分類
HY-10403A 関連分類
Powered by Bioz