AZ-4217
AZ-4217 is an inhibitor for β-site amyloid precursor protein cleavage enzyme 1 (BACE1), with IC50 of 160 pM in human SH-SY5Y cells. AZ-4217 reduces amyloid deposition in Tg2576 mouse models, and is used for Alzheimer’s Disease research.
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- CAS 番号: 1383846-83-0
- 分子式: C30H25FN4O
- 分子量:476.54
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Cerebral cortex neuron | IC50 |
2.6 nM
Compound: (R)-41
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Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISA
Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISA
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[PMID: 22924815] |
| CHO | IC50 |
2.8 μM
Compound: (R)-41
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Inhibition of human ERG expressed in CHO cells by IonWorks assay
Inhibition of human ERG expressed in CHO cells by IonWorks assay
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[PMID: 22924815] |
| SH-SY5Y | IC50 |
0.16 nM
Compound: (R)-41
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Inhibition of BACE1 in human SH-SY5Y cells assessed as inhibition of sAPPbeta release after 16 hrs by immunoassay
Inhibition of BACE1 in human SH-SY5Y cells assessed as inhibition of sAPPbeta release after 16 hrs by immunoassay
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[PMID: 22924815] |
化学情報
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CAS 番号 1383846-83-0
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分子量 476.54
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分子式 C30H25FN4O
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SMILES
O=C(C(C)=C1)N(CC)C=C1[C@@]2(C3=CC(C4=CN=CC(C#CC)=C4)=CC=C3)C5=CC=CC(F)=C5C(N)=N2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AZ-4217 関連分類
HY-18112 関連分類
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