Bathocuproine
Based on 1 Customer Validation
Bathocuproine is a phenanthroline chelator that binds specifically to Cu+. Bathocuproine preferentially binds Cu+ over Cu2+ to form a chromogenic complex, which is used to detect the oxidation state of copper in biomolecules. Bathocuproine undergoes concentration-dependent self-association to form dimers, and it can engage in aromatic stacking interactions with aromatic residues of Aβ (Kd ≈ 1 mM). Bathocuproine is applicable to research related to Alzheimer's disease.
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- 純度 : 98.01%
- CAS 番号: 4733-39-5
- 分子式: C26H20N2
- 分子量:360.46
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保管条件:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-D0006
BathophenanthrolineActive Compound -
HY-121310
PhthalocyaninePhotosensitizer -
HY-W034953
Bathocuproine disulfonate disodiumBiochemical Assay Reagent -
HY-19204
Zinc phthalocyaninePhotooxidant -
HY-W025445
Spiro-MeOTADHole Transport Layer Material -
HY-W073017
Copper(II) Phthalocyanine (purified by sublimation)Metal-organic Framework -
HY-W004583
2,9-Dichloro-1,10-phenanthrolineMetal-organic Framework -
HY-Y1841
o-Phenanthroline monohydrateMMP Inhibitor -
HY-W116336B
Zinc oxide, 99.99% metals basisBiochemical Assay Reagents -
HY-W116336D
Zinc oxide, <100 nm particle sizeNitrate Reductase Activator -
HY-W008874
meso-Tetra(4-pyridyl)porphineTop1 Inhibitor -
HY-W035136
Meso-tetrakis(4-aminophenyl)porphyrinEndogenous Metabolite
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| ScN2a | IC50 |
80 nM
Compound: Bathocuproine
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Inhibition of PrP-res formation in mouse ScN2a cells relative to control
Inhibition of PrP-res formation in mouse ScN2a cells relative to control
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[PMID: 16987659] |
体外実験
Bathocuproine (0.32-3.16 mM) undergoes reversible monomer-dimer self-association in aqueous solution at 25 °C, with an association constant of 0.64 mM-1.
Bathocuproine (0.32-3.16 mM) binds to the Aβ40 peptide only in its dimeric form in aqueous solution at 25 °C, with a dissociation constant of approximately 1 mM under conditions where the dimer accounts for ≥ 40% of the total[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 4733-39-5
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性状 Solid
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分子量 360.46
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分子式 C26H20N2
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Color Light yellow to brown
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SMILES
N=1C(=CC(C=2C=CC=CC2)=C3C=CC4=C(N=C(C=C4C=5C=CC=CC5)C)C13)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
純度とドキュメンテーション
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データシート (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Chen D, et al. An improved Bathocuproine assay for accurate valence identification and quantification of copper bound by biomolecules. Anal Biochem. 2016;497:27-35. [Content Brief]
[2]. Yao S, et al. Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid beta-peptide by NMR. J Pept Sci. 2004;10(4):210-217. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Bathocuproine 関連分類
HY-D0005 関連分類
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