Bathocuproine
Based on 1 Customer Validation
Bathocuproine is a phenanthroline chelator that binds specifically to Cu+. Bathocuproine preferentially binds Cu+ over Cu2+ to form a chromogenic complex, which is used to detect the oxidation state of copper in biomolecules. Bathocuproine undergoes concentration-dependent self-association to form dimers, and it can engage in aromatic stacking interactions with aromatic residues of Aβ (Kd ≈ 1 mM). Bathocuproine is applicable to research related to Alzheimer's disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.01%
- CAS 番号: 4733-39-5
- 分子式: C26H20N2
- 分子量:360.46
-
保管条件:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-D0006
BathophenanthrolineActive Compound -
HY-121310
PhthalocyaninePhotosensitizer -
HY-W034953
Bathocuproine disulfonate disodiumBiochemical Assay Reagent -
HY-19204
Zinc phthalocyaninePhotooxidant -
HY-W025445
Spiro-MeOTADHole Transport Layer Material -
HY-W073017
Copper(II) Phthalocyanine (purified by sublimation)Metal-organic Framework -
HY-W004583
2,9-Dichloro-1,10-phenanthrolineMetal-organic Framework -
HY-Y1841
o-Phenanthroline monohydrateMMP Inhibitor -
HY-W116336B
Zinc oxide, 99.99% metals basisBiochemical Assay Reagents -
HY-W116336D
Zinc oxide, <100 nm particle sizeNitrate Reductase Activator -
HY-W008874
meso-Tetra(4-pyridyl)porphineTop1 Inhibitor -
HY-W035136
Meso-tetrakis(4-aminophenyl)porphyrinEndogenous Metabolite
生物活性
製品説明
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| ScN2a | IC50 |
80 nM
Compound: Bathocuproine
|
Inhibition of PrP-res formation in mouse ScN2a cells relative to control
Inhibition of PrP-res formation in mouse ScN2a cells relative to control
|
[PMID: 16987659] |
体外実験
Bathocuproine (0.32-3.16 mM) undergoes reversible monomer-dimer self-association in aqueous solution at 25 °C, with an association constant of 0.64 mM-1.
Bathocuproine (0.32-3.16 mM) binds to the Aβ40 peptide only in its dimeric form in aqueous solution at 25 °C, with a dissociation constant of approximately 1 mM under conditions where the dimer accounts for ≥ 40% of the total[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
-
CAS 番号 4733-39-5
-
性状 Solid
-
分子量 360.46
-
分子式 C26H20N2
-
Color Light yellow to brown
-
SMILES
N=1C(=CC(C=2C=CC=CC2)=C3C=CC4=C(N=C(C=C4C=5C=CC=CC5)C)C13)C
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
プロトコル
-
Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
純度とドキュメンテーション
-
データシート (271 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Chen D, et al. An improved Bathocuproine assay for accurate valence identification and quantification of copper bound by biomolecules. Anal Biochem. 2016;497:27-35. [Content Brief]
[2]. Yao S, et al. Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid beta-peptide by NMR. J Pept Sci. 2004;10(4):210-217. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Bathocuproine 関連分類
HY-D0005 関連分類
Powered by Bioz