Bexirestrant
Based on 1 Customer Validation
Bexirestrant is an orally active ER-α degrader. Bexirestrant can be used for the research of antiestrogen, antineoplastic.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.26%
- CAS 番号: 2505067-70-7
- 分子式: C29H26F3NO2
- 分子量:477.52
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保管条件:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Bexirestrant (compound Formula Ia) inhibits the growth of wild type (WT), Y537S and D538G mutated MCF-7 cells with IC50s of 0.3. 6.0, 2.2 nM, respectively[1].
Bexirestrant induces the ER-α degradation in WT, Y537S and D538G mutated MCF-7 cells with IC50s of 0.3. 19.6, 12.7 nM, respectively[1].
Bexirestrant shows 16.3% ER-α remaining in WT MCF-7 cells at concentration of 1 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
| Tmax (h) | Cmax (ng/mL) | AUClast (hr× ng/mL) | AUCinf_obs (hr×ng/mL) | T1/2 (h) |
| 4.00 | 343 | 7582 | 9804 | 26 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female athymic nude mice harboring subcutaneous MCF7-Y537S xenograft[1]
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Dosage:50mg/kg
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Administration:p.o. for 28 days
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Result:Showed 56% tumor growth inhibition compared to vehicle group after 28 days.
化学情報
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CAS 番号 2505067-70-7
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性状 Solid
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分子量 477.52
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分子式 C29H26F3NO2
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Color White to off-white
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SMILES
CC1=C(C2=CC(F)=CC(F)=C2)[C@H](C3=CC=C(C=C3)/C=C/CN4CC(C4)CF)OC5=CC(O)=CC=C51
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Bexirestrant 関連分類
HY-145556 関連分類
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