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製品番号: HY-183960

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BPyO-34

BPyO-34 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC₅₀ of 0.52 μM against human targets. BPyO-34 inhibits the activity of ASK1 in in vitro kinase assays. BPyO-34 can be used in research related to various diseases such as diabetes and cancer.

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CAS 番号: 890601-68-0
分子式: C₃₂H₂₉FN₂O₅S
分子量:572.65

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

BPyO-34 構造式

CAS 番号: 890601-68-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

BPyO-34 inhibits recombinant human ASK1 catalytic subunit with an IC₅₀ of 0.52 μM in an in vitro biochemical kinase assay^[1].
BPyO-34 (10 μM) shows preferential inhibition of recombinant human ASK1 over recombinant human CK2, FGFR1, Tie2, JNK3, and Aurora A^[1].
BPyO-34 binds to the ATP-binding pocket of human ASK1 via specific hydrogen bonding, hydrophobic, and sulfur-π interactions with key amino acid residues^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 890601-68-0
分子量 572.65
分子式 C₃₂H₂₉FN₂O₅S
SMILES

O=C(C1=C(C(N(C1C2=CC(OCCC(C)C)=CC=C2)C3=NC4=C(S3)C=C(F)C=C4)=O)O)C5=CC=C6OC(CC6=C5)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Starosyla SA, et al. Identification of apoptosis signal-regulating kinase 1 (ASK1) inhibitors among the derivatives of benzothiazol-2-yl-3-hydroxy-5-phenyl-1,5-dihydro-pyrrol-2-one. Bioorg Med Chem. 2015;23(10):2489-2497. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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