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製品番号: HY-N19721

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Brasimarin B

Brasimarin B is a 4-phenylcoumarin compound found in the stem bark of Calophyllum brasiliense. Brasimarin B inhibits TPA (HY-18739)-induced EBV-EA activation in Raji cells.

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CAS 番号: 514214-46-1
分子式: C₂₅H₂₆O₆
分子量:422.47

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Brasimarin B 構造式

CAS 番号: 514214-46-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Brasimarin B is a 4-phenylcoumarin compound found in the stem bark of Calophyllum brasiliense. Brasimarin B inhibits TPA (HY-18739)-induced EBV-EA activation in Raji cells^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
Raji	IC₅₀	342 molar ratio Compound: 3	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as early antigen activation after 48 hrs relative to control Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as early antigen activation after 48 hrs relative to control	[PMID: 12662094]

体外実験

Brasimarin B (Compound 3) (0.32-32 nmol; 48 h) inhibits TPA (HY-18739) (20 ng/mL)-induced EBV-EA activation in Raji cells with an IC₅₀ of 10.944 nmol, completely blocking activation at the highest tested concentration without significant cell viability loss^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 514214-46-1
分子量 422.47
分子式 C₂₅H₂₆O₆
SMILES

CCC(C)C(C1=C(O)C(CC(O2)C(C)(O)C)=C2C(C(C3=CC=CC=C3)=C4)=C1OC4=O)=O
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Ito C, et al. Chemical constituents of Calophyllum brasiliense. 2. Structure of three new coumarins and cancer chemopreventive activity of 4-substituted coumarins. J Nat Prod. 2003;66(3):368-371. [Content Brief]

[2]. César GZ, et al. Inhibition of HIV-1 reverse transcriptase, toxicological and chemical profile of Calophyllum brasiliense extracts from Chiapas, Mexico. Fitoterapia. 2011;82(7):1027-1034. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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