Rondaptivon pegol sodium
Based on 1 Customer Validation
Rondaptivon pegol (BT200) sodium is a pegylated aptamer targeting von Willebrand factor (VWF), with an EC50 of 33 nM in humans. Rondaptivon pegol sodium effectively alleviates acute myocardial ischemia-reperfusion injury in mice by inhibiting VWF activity, reducing microvascular obstruction, inflammatory responses and cardiomyocyte apoptosis (apoptosis). Rondaptivon pegol sodium inhibits the binding of VWF to platelet glycoprotein GPIb, thereby preventing arterial thrombosis in cynomolgus monkeys. Rondaptivon pegol sodium can be used in research related to arterial thrombosis, stroke, myocardial infarction and myocardial ischemia-reperfusion injury.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 93.15%
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Rondaptivon pegol sodium (3 μg/mL; 60 min) reduces VWF activity in citrated human plasma to 28.5% of the normal level[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
Rondaptivon pegol sodium (0.1-5.0 mg/kg; intravenous injection; single administration) attenuates acute myocardial ischemia-reperfusion injury in mice by targeting VWF[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 6-8 weeks old, wild-type, myocardial ischemia-reperfusion injury model)[2]
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Dosage:0.1 mg/kg; 0.5 mg/kg; 5.0 mg/kg
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Administration:i.v.; single dose at reperfusion start
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Result:Accumulated in ischemic myocardium, inhibited VWF A1 activity, prolonged bleeding time, reduced microvascular obstruction, alleviated inflammatory response and cardiomyocyte apoptosis, significantly decreased infarct size, and improved left ventricular ejection fraction and fractional shortening.
化学情報
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性状 Solid
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Color Off-white to light yellow
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SMILES
[Rondaptivon pegol sodium]
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別名
BT200 sodium
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (1518 KB)
参考文献
[1]. Zhu S, et al. Potent and rapid reversal of the von Willebrand factor inhibitor aptamer BT200. J Thromb Haemost. 2020 Jul;18(7):1695-1704. [Content Brief]
[2]. Chen X, et al. Aptamer BT200 is protective against myocardial ischemia-reperfusion injury in mice. J Thromb Haemost. 2025;23(1):222-234. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Rondaptivon pegol sodium 関連分類
HY-153999A 関連分類
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