BW A4C
BW A4C is a selective 5-lipoxygenase (5-LO) inhibitor. BW A4C is also an inhibitor of linoleic acid 8R-dioxygenase in Gaeumannomyces graminis, with an IC50 value of 0.2 μM. BW A4C can be used in research on diseases such as asthma.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 106328-57-8
- 分子式: C17H17NO3
- 分子量:283.32
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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5-LO |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PMNL | IC50 |
0.05 μM
Compound: BWA4C
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Inhibition of 5-lipoxygenase in cell free S100 freshly isolated human PMNL cells assessed as inhibition of A23187-stimulated 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis
Inhibition of 5-lipoxygenase in cell free S100 freshly isolated human PMNL cells assessed as inhibition of A23187-stimulated 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis
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[PMID: 22551629] |
| PMNL | IC50 |
0.11 μM
Compound: 8, BW-A4C
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Inhibition of 5-LO in PMNL cells
Inhibition of 5-LO in PMNL cells
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[PMID: 19053751] |
| RBL-1 | IC50 |
100 nM
Compound: 4 (BW-A4C)
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Compound was tested for in vitro inhibition on broken human PMNL
Compound was tested for in vitro inhibition on broken human PMNL
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[PMID: 8709092] |
| U-937 | IC50 |
>30 μM
Compound: BWA4C
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Cytotoxicity against human U937 cells assessed as cell viability after 48 hrs by WST-1 assay
Cytotoxicity against human U937 cells assessed as cell viability after 48 hrs by WST-1 assay
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[PMID: 22551629] |
化学情報
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CAS 番号 106328-57-8
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分子量 283.32
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分子式 C17H17NO3
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SMILES
CC(N(O)C/C=C/C1=CC=CC(OC2=CC=CC=C2)=C1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Payne AN, et al. Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 1991;34:189-99. [Content Brief]
[2]. Brodowsky ID, et al. BW A4C and other hydroxamic acids are potent inhibitors of linoleic acid 8R-dioxygenase of the fungus Gaeumannomyces graminis. Eur J Pharmacol. 1994 Mar 11;254(1-2):43-7. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BW A4C 関連分類
HY-136923 関連分類
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