クリセン
Based on 1 publication(s) in Google Scholar
Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties.
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- 純度: 99.71%
- CAS 番号: 218-01-9
- 分子式: C18H12
- 分子量:228.29
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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MedChemExpress（MCE）の使用を引用している文献 Chrysene
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生物活性
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
Chrysene can be used in animal modeling to create hepatic tumor models.
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Administration: 700 or 2800 nmol/Mouse • ip • administered on postnatal days 1, 8, and 15
On Day 1, inject 100 or 400 nmol of Chrysene, with a DMSO volume of 10 μL.
On Day 8, inject 200 or 800 nmol of Chrysene, with a DMSO volume of 20 μL.
On Day 15, inject 400 or 1600 nmol of Chrysene, with a DMSO volume of 40 μL.
(2) The administration is performed under dim light, and the mice are euthanized one year later to determine the incidence of liver tumors.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 218-01-9
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性状 Solid
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分子量 228.29
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分子式 C18H12
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Color White to off-white
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SMILES
C12=CC=CC=C1C=CC3=C4C=CC=CC4=CC=C23
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別名
Chrysene
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
DMSO : 2 mg/mL (8.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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参考文献
[1]. Vaidya S, et al. Degradation of Chrysene by Enriched Bacterial Consortium. Front Microbiol. 2018 Jun 26;9:1333. [Content Brief]
[2]. Wislocki PG, et al. Tumorigenicity of nitrated derivatives of pyrene, benz[a]anthracene, chrysene and benzo[a]pyrene in the newborn mouse assay. Carcinogenesis. 1986 Aug;7(8):1317-22. [Content Brief]
[3]. Tao LP, et al. Chrysene, a four-ring polycyclic aromatic hydrocarbon, induces hepatotoxicity in mice by activation of the aryl hydrocarbon receptor (AhR). Chemosphere. 2021 Aug;276:130108. [Content Brief]
[4]. Jacob J, et al. Monooxygenase induction by various xenobiotics and its influence on rat liver microsomal metabolism of chrysene in comparison to benz[a]anthracene. Cancer Lett. 1987 Jan;34(1):91-102. [Content Brief]
[5]. Hodgson RM, et al. Metabolic activation of chrysene in mouse skin: evidence for the involvement of a triol-epoxide. Carcinogenesis. 1983 Dec;4(12):1639-43. [Content Brief]
[6]. Rice JE, et al. Comparative tumor-initiating activity of methylene-bridged and bay-region methylated derivatives of benz[a]anthracene and chrysene. Carcinogenesis. 1988 Dec;9(12):2275-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.3804 mL | 21.9020 mL | 43.8039 mL | 109.5098 mL |
| 5 mM | 0.8761 mL | 4.3804 mL | 8.7608 mL | 21.9020 mL |
Chrysene 関連分類
HY-121107 関連分類
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