Cl-HIBO
Based on 1 Customer Validation
Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM). Cl-HIBO has desensitizing properties.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.0%
- CAS 番号: 909400-43-7
- 分子式: C6H7ClN2O4
- 分子量:206.58
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
EC50: 4.7, 1.7, 2700 and 1300 μM=GluR1/2/3/4[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Oocyte | EC50 |
1.7 μM
Compound: 3 (Cl-HIBO)
|
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 2 (GluR2) using rat cortical slice model in Xenopus laevis oocytes
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 2 (GluR2) using rat cortical slice model in Xenopus laevis oocytes
|
[PMID: 12747796] |
| Oocyte | EC50 |
1.7 μM
Compound: 3, Cl-HIBO
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Agonist activity at rat recombinant GluA2(Q)i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
Agonist activity at rat recombinant GluA2(Q)i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
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[PMID: 21067182] |
| Oocyte | EC50 |
1.7 μM
Compound: Cl-HIBO
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Agonist activity at recombinant GluA2 receptor flop isoform expressed in Xenopus oocytes
Agonist activity at recombinant GluA2 receptor flop isoform expressed in Xenopus oocytes
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[PMID: 20096591] |
| Oocyte | EC50 |
1300 μM
Compound: 3 (Cl-HIBO)
|
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 4 (GluR4) using rat cortical slice model in Xenopus laevis oocytes
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 4 (GluR4) using rat cortical slice model in Xenopus laevis oocytes
|
[PMID: 12747796] |
| Oocyte | EC50 |
1300 μM
Compound: 3, Cl-HIBO
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Agonist activity at rat recombinant GluA4i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
Agonist activity at rat recombinant GluA4i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
|
[PMID: 21067182] |
| Oocyte | EC50 |
1300 μM
Compound: Cl-HIBO
|
Agonist activity at recombinant GluA4 receptor flip isoform expressed in Xenopus oocytes
Agonist activity at recombinant GluA4 receptor flip isoform expressed in Xenopus oocytes
|
[PMID: 20096591] |
| Oocyte | EC50 |
2700 μM
Compound: 3 (Cl-HIBO)
|
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 3 (GluR3) using rat cortical slice model in Xenopus laevis oocytes
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 3 (GluR3) using rat cortical slice model in Xenopus laevis oocytes
|
[PMID: 12747796] |
| Oocyte | EC50 |
2700 μM
Compound: 3, Cl-HIBO
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Agonist activity at rat recombinant GluA3i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
Agonist activity at rat recombinant GluA3i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
|
[PMID: 21067182] |
| Oocyte | EC50 |
2700 μM
Compound: Cl-HIBO
|
Agonist activity at recombinant GluA3 receptor flip isoform expressed in Xenopus oocytes
Agonist activity at recombinant GluA3 receptor flip isoform expressed in Xenopus oocytes
|
[PMID: 20096591] |
| Oocyte | EC50 |
4.7 μM
Compound: 3 (Cl-HIBO)
|
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 1 (GluR1) using rat cortical slice model in Xenopus laevis oocytes
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 1 (GluR1) using rat cortical slice model in Xenopus laevis oocytes
|
[PMID: 12747796] |
| Oocyte | EC50 |
4.7 μM
Compound: 3, Cl-HIBO
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Agonist activity at rat recombinant GluA1i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
Agonist activity at rat recombinant GluA1i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
|
[PMID: 21067182] |
| Oocyte | EC50 |
4.7 μM
Compound: Cl-HIBO
|
Agonist activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes
Agonist activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes
|
[PMID: 20096591] |
Cl-HIBO is a strongly desensitizing full agonist at GluR1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 909400-43-7
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性状 Solid
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分子量 206.58
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分子式 C6H7ClN2O4
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Color Light brown to gray
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SMILES
O=C(O)C(N)CC(ON1)=C(Cl)C1=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
H2O : 4.5 mg/mL (21.78 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (251 KB)
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- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.8407 mL | 24.2037 mL | 48.4074 mL | 121.0185 mL |
| 5 mM | 0.9681 mL | 4.8407 mL | 9.6815 mL | 24.2037 mL | |
| 10 mM | 0.4841 mL | 2.4204 mL | 4.8407 mL | 12.1018 mL | |
| 15 mM | 0.3227 mL | 1.6136 mL | 3.2272 mL | 8.0679 mL | |
| 20 mM | 0.2420 mL | 1.2102 mL | 2.4204 mL | 6.0509 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Cl-HIBO 関連分類
HY-103229 関連分類
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