CLB-016
CLB-016 is a potent Hypoxia-inducible factor (HIF-1) inhibitor with an IC50 of 19.1 μM. CLB-016 significantly suppresses HIF-1-mediated hypoxia response.
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- CAS 番号: 1005636-29-2
- 分子式: C17H20N6O3
- 分子量:356.38
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-1080 | IC50 |
15.1 μM
Compound: 1, CLB-016
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Inhibition of cell proliferation of human HT1080 cells after 72 hrs by WST-8 dye based cell counting assay
Inhibition of cell proliferation of human HT1080 cells after 72 hrs by WST-8 dye based cell counting assay
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[PMID: 25773014] |
| HT-1080 | IC50 |
19.1 μM
Compound: 1, CLB-016
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Inhibition of HIF1 in human HT1080 cells transfected with 5xHRE/pGL3/VEGF/E1b reporter plasmid pre-incubated for 1 hr followed by incubation under hypoxia conditions for 24 hrs by HRE-driven luciferase reporter gene assay
Inhibition of HIF1 in human HT1080 cells transfected with 5xHRE/pGL3/VEGF/E1b reporter plasmid pre-incubated for 1 hr followed by incubation under hypoxia conditions for 24 hrs by HRE-driven luciferase reporter gene assay
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[PMID: 25773014] |
化学情報
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CAS 番号 1005636-29-2
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分子量 356.38
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分子式 C17H20N6O3
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SMILES
O=C(C1=NN(CC)C=C1NC(C2=CC=C(CN3N=C(C)C=C3C)O2)=O)N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CLB-016 関連分類
HY-113662 関連分類
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