Clomesone
Clomesone (NSC 338947) is a compound with antitumor activity. Clomesone induces the formation of cross-links between DNA strands in cell lines. Clomesone is inactive against most human colorectal cancer solid tumor cell lines in vitro, has no significant activity against mouse tumors in vivo, and is accompanied by bone marrow suppression. Its pharmacokinetic behavior indicates that it cannot reach effective concentrations at the tumor site.
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- CAS 番号: 88343-72-0
- 分子式: C4H9ClO5S2
- 分子量:236.69
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
3 μM
Compound: 10
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In vitro growth inhibition against L1210 murine leukemia cells
In vitro growth inhibition against L1210 murine leukemia cells
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[PMID: 2342050] |
化学情報
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CAS 番号 88343-72-0
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分子量 236.69
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分子式 C4H9ClO5S2
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SMILES
O=S(OCCCl)(CS(=O)(C)=O)=O
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別名
NSC 338947; CIEtSoSo
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Pre-clinical evaluation of a novel chloroethylating agent, Clomesone [Content Brief]
[2]. M E Dolan, et al. Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate. Cancer Res. 1988 Jul 1;48(13):3603-6. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Clomesone 関連分類
HY-W848341 関連分類
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