製品番号: HY-123986

CTPI-2

(別名: 2-(4-chloro-3-nitrobenzenesulfonamido)benzoic acid)

15 Cited Publications

カスタマーレビュー

Based on 15 publication(s) in Google Scholar

CTPI-2 is a third-generation mitochondrial citrate carrier SLC25A1 inhibitor with a K_D of 3.5 μM. CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet. Antitumor activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.99%
CAS 番号: 68003-38-3
分子式: C₁₃H₉ClN₂O₆S
分子量:356.74

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months

CTPI-2 構造式

CAS 番号: 68003-38-3

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

KD: 3.5 μM (SLC25A1)^[1]

体内実験

CTPI-2 is a unique regulator of glycolysis that limits the metabolic plasticity of cancer stem cells (CSCs). CTPI-2 (26 mg/kg; i.p.) inhibits tumor growth in in vivo models of non-small cell lung cancer (NSCLC)^[1].
CTPI-2 (50 mg/kg; i.p.; alternate days for 12 weeks) completely averts weight gain in the prevention study and leads to significant weight loss in the reversion study^[2].
CTPI-2 prevents steatohepatitis and normalizes glucose tolerance. CTPI-2 lowers the levels of circulating IL-6 while increasing anti-inflammatory IL-4 and IL-10 and also reduced the monocyte chemoattractant protein-1 and monokine-induced by interferon-γ that attract neutrophils and monocytes. CTPI-2 regulates the citrate pool, the lipogenic and the gluconeogenic pathways^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J mice (HFD-fed mice)^[2]
Dosage:

50 mg/kg
Administration:

Alternate days via the intraperitoneal route for 12 weeks
Result:

Completely averted weight gain in the prevention study and led to significant weight loss in the reversion study.

化学情報

CAS 番号 68003-38-3
性状 Solid
分子量 356.74
分子式 C₁₃H₉ClN₂O₆S
Color Off-white to light yellow
SMILES

O=C(O)C1=CC=CC=C1NS(=O)(C2=CC=C(Cl)C([N+]([O-])=O)=C2)=O
別名

2-(4-chloro-3-nitrobenzenesulfonamido)benzoic acid
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

Publications (15)

All Cell Imaging/StainingRT-PCRCell Migration/Invasion AssayELISAFlow Cytometry

Sort by:

Journal Impact Factor

Redox Biol

Central carbon metabolism exhibits unique characteristics during the handling of fungal patterns by monocyte-derived dendritic cells. [Abstract]

2024 Jul:73:103187. PMID: 38744190

CTPI-2 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Jul:73:103187. [Abstract]

ROS production by MDDCs labeled with 2′,7′-dichlorofluorescein diacetate and stimulated for 30 min with zymosan in the presence of 10 μM CTPI-2. Results are expressed as per cent values of zymosan effect.
Cell Death Dis

ACSS1 co-opts acetyl-CoA metabolism to drive DNA repair and undermine radiotherapy efficacy in breast cancer. [Abstract]

2025 Dec 18. PMID: 41413018
Cell Death Discov

A novel SLC25A1 inhibitor, parthenolide, suppresses the growth and stemness of liver cancer stem cells with metabolic vulnerability. [Abstract]

2023 Sep 23;9(1):350. PMID: 37741815
NPJ Precis Oncol

SLC25A1 upregulation promotes HNSCC cisplatin resistance via H3K27ac-mediated cellular senescence. [Abstract]

2026 Apr 10;10(1):226. PMID: 41963605
Apoptosis

Mitochondrial CLPB is a pro-survival factor at the onset of granulocytic differentiation of mouse myeloblastic cells. [Abstract]

2025 Feb;30(1-2):334-348. PMID: 39644357
EMBO J

ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration. [Abstract]

2022 Apr 19;41(8):e109463. PMID: 35229328

CTPI-2 purchased from MedChemExpress. Usage Cited in: EMBO J. 2022 Apr 19;41(8):e109463. [Abstract]

Effect of 10 μM CTPI-2 on the expression of cytokine mRNA.

CTPI-2 purchased from MedChemExpress. Usage Cited in: EMBO J. 2022 Apr 19;41(8):e109463. [Abstract]

Assay of cytokine protein expression in the supernatants of MDDCs stimulated overnight with zymosan in the presence and absence of CTPI-2.

CTPI-2 purchased from MedChemExpress. Usage Cited in: EMBO J. 2022 Apr 19;41(8):e109463. [Abstract]

The effects of CTPI-2 (50 mg/kg, i.p.) on HSC expansion in the early phase after the administration of 5-FU. Numbers in the dot plots represent the frequencies of the indicated fractions within total BM cells.
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
Int J Oncol

SLC25A1 promotes lymph node metastasis of esophageal squamous cell carcinoma by regulating lipid metabolism. [Abstract]

2025 Feb;66(2):15. PMID: 39821659

CTPI-2 purchased from MedChemExpress. Usage Cited in: Int J Oncol. 2025 Feb;66(2):15. [Abstract]

Migration ability of ESCC cells treated with CTPI-2 (30 μM) was detected via a wound healing assay.
Int J Oncol

SUCLG1 promotes aerobic respiration and progression in plexiform neurofibroma. [Abstract]

2025 Feb;66(2):10. PMID: 39749698
Cancer Sci

Noncanonical TCA cycle fosters canonical TCA cycle and mitochondrial integrity in acute myeloid leukemia. [Abstract]

2025 Jan;116(1):152-163. PMID: 39479926
bioRxiv

Citrate Compartmentalization Controls Calcium-Dependent Cytokine Production in Effector T Cells. [Abstract]

2026 Jun 12:2026.06.11.731694. PMID: 42327233
Research Square Preprint

2024 Jan 25.
Chemrxiv

2023 Nov 1.
bioRxiv

Lipin-1 restrains macrophage lipid synthesis to promote inflammation resolution. [Abstract]

2023 Oct 25:2023.10.23.563587. PMID: 37961352
Universität Duisburg-Essen

2022 Sep.

溶剤 & 溶解度

体外:

DMSO : 116.67 mg/mL (327.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8032 mL

14.0158 mL

28.0316 mL

5 mM

0.5606 mL

2.8032 mL

5.6063 mL

10 mM

0.2803 mL

1.4016 mL

2.8032 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (5.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (5.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (5.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Tan M, et al. Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. Cell Death Differ. 2020;27(7):2143-2157. [Content Brief]

[2]. Fernandez HR, et al. The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer. Cell Death Differ. 2018;25(7):1239-1258. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8032 mL	14.0158 mL	28.0316 mL	70.0791 mL
	5 mM	0.5606 mL	2.8032 mL	5.6063 mL	14.0158 mL
	10 mM	0.2803 mL	1.4016 mL	2.8032 mL	7.0079 mL
	15 mM	0.1869 mL	0.9344 mL	1.8688 mL	4.6719 mL
	20 mM	0.1402 mL	0.7008 mL	1.4016 mL	3.5040 mL
	25 mM	0.1121 mL	0.5606 mL	1.1213 mL	2.8032 mL
	30 mM	0.0934 mL	0.4672 mL	0.9344 mL	2.3360 mL
	40 mM	0.0701 mL	0.3504 mL	0.7008 mL	1.7520 mL
	50 mM	0.0561 mL	0.2803 mL	0.5606 mL	1.4016 mL
	60 mM	0.0467 mL	0.2336 mL	0.4672 mL	1.1680 mL
	80 mM	0.0350 mL	0.1752 mL	0.3504 mL	0.8760 mL
	100 mM	0.0280 mL	0.1402 mL	0.2803 mL	0.7008 mL

Keywords

CTPI-2

15 Cited Publications

100 mg お問い合わせ

Subscribe to the

MedChemExpress

Newsletter

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

CTPI-2

Reprogramming Compound Library

Glycolysis Compound Library

Glutamine Metabolism Compound Library

Anti-Lung Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Mitochondria-Targeted Compound Library

Glucose Metabolism Compound Library

Cuproptosis Compound Library

Cancer Stem Cells Compound Library

Mitochondrial Protection Compound Library

Metabolic Enzyme Compound Library

Macrophage Related Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Stem Cell Signaling Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

MedChemExpress（MCE）の使用を引用している文献 CTPI-2

生物活性

化学情報

Publications (15)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

CTPI-2

Reprogramming Compound Library

Glycolysis Compound Library

Glutamine Metabolism Compound Library

Anti-Lung Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Mitochondria-Targeted Compound Library

Glucose Metabolism Compound Library

Cuproptosis Compound Library

Cancer Stem Cells Compound Library

Mitochondrial Protection Compound Library

Metabolic Enzyme Compound Library

Macrophage Related Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Stem Cell Signaling Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

MedChemExpress（MCE）の使用を引用している文献 CTPI-2

生物活性

化学情報

Publications (15)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

CTPI-2 関連分類

HY-123986 関連分類