CVN293
Based on 1 Customer Validation
CVN293 is a selective and brain permeable potassium ion (K+) channel KCNK13 inhibtor with IC50s of 41 nM and 28 nM for hKCNK13 and mKCNK13, respectively. CVN293 potently inhibits the NLRP3-inflammasome mediated production of the proinflammatory cytokine IL-1β in microglia.
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- 純度: 99.91%
- CAS 番号: 2815296-08-1
- 分子式: C14H10FN7O
- 分子量:311.27
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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生物活性
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hKCNK13 41 nM (IC50) |
mKCNK13 28 nM (IC50) |
hKCNK6 >30000 nM (IC50) |
hKCNK2 >30000 nM (IC50) |
CVN293 (0.05, 0.5, 5 μM) demonstrates a concentration-dependent inhibition of the NLRP3-inflammasome mediated production of IL-1β from LPS-primed murine microglia[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| IV (0.5 mg/kg; rat) | PO (3 mg/kg; rat) | IV (1 mg/kg; dog) | PO (10 mg/kg; dog) | IV (1 mg/kg; cynomolgus monkey) | PO (3 mg/kg; cynomolgus monkey) | |
| Tmax (h) | 1.0 | 1.25 | 1.0 | |||
| Cmax (ng/mL) | 468 | 241 | 165 | |||
| AUC0-∞ (ng•h/mL) | 222 | 1236 | 438 | 630 | 782 | 546 |
| t1/2 (h) | 1.0 | 2.0 | 0.5 | 2.6 | 1.1 | 1.9 |
| CLp (mL/min/kg) | 35 | 38 | 22 | |||
| Vss (L/kg) | 1.85 | 1.42 | 1.45 | |||
| F (%) | 87 | 41 | 24 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2815296-08-1
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性状 Solid
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分子量 311.27
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分子式 C14H10FN7O
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Color White to light yellow
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SMILES
NC1=NON=C1C2=NC3=CC=CC(F)=C3N2CC4=NN=CC=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 5 mg/mL (16.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2126 mL | 16.0632 mL | 32.1265 mL | 80.3161 mL |
| 5 mM | 0.6425 mL | 3.2126 mL | 6.4253 mL | 16.0632 mL | |
| 10 mM | 0.3213 mL | 1.6063 mL | 3.2126 mL | 8.0316 mL | |
| 15 mM | 0.2142 mL | 1.0709 mL | 2.1418 mL | 5.3544 mL |
CVN293 関連分類
HY-158155 関連分類
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