CYM50179
Based on 1 publication(s) in Google Scholar
CYM50179 (compound 22n) is a potent and selective S1P4-R (Sphingosine-1-phosphate4 receptor) agonist with an EC50 of 46 nM.
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- 純度: 96.06%
- CAS 番号: 1355026-47-9
- 分子式: C13H9Br2Cl2NO2
- 分子量:441.93
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 CYM50179
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生物活性
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S1PR4 46 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U2OS | EC50 |
46 nM
Compound: 22n, CYM50179
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Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
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[PMID: 22119461] |
化学情報
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CAS 番号 1355026-47-9
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性状 Solid
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分子量 441.93
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分子式 C13H9Br2Cl2NO2
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Color White to off-white
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SMILES
ClC1=CC(Cl)=C(C=C1)OCCOC2=C(N=C(C=C2)Br)Br
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
溶剤 & 溶解度
DMSO : 62.5 mg/mL (141.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (641 KB)
- English - EN (641 KB)
- Français - FR (641 KB)
- Deutsch - DE (641 KB)
- Norwegian - NO (641 KB)
- Español - ES (641 KB)
- Swedish - SV (641 KB)
- Italian - IT (641 KB)
- Korean - KR (641 KB)
- Portuguese - PT (641 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2628 mL | 11.3140 mL | 22.6280 mL | 56.5700 mL |
| 5 mM | 0.4526 mL | 2.2628 mL | 4.5256 mL | 11.3140 mL | |
| 10 mM | 0.2263 mL | 1.1314 mL | 2.2628 mL | 5.6570 mL | |
| 15 mM | 0.1509 mL | 0.7543 mL | 1.5085 mL | 3.7713 mL | |
| 20 mM | 0.1131 mL | 0.5657 mL | 1.1314 mL | 2.8285 mL | |
| 25 mM | 0.0905 mL | 0.4526 mL | 0.9051 mL | 2.2628 mL | |
| 30 mM | 0.0754 mL | 0.3771 mL | 0.7543 mL | 1.8857 mL | |
| 40 mM | 0.0566 mL | 0.2829 mL | 0.5657 mL | 1.4143 mL | |
| 50 mM | 0.0453 mL | 0.2263 mL | 0.4526 mL | 1.1314 mL | |
| 60 mM | 0.0377 mL | 0.1886 mL | 0.3771 mL | 0.9428 mL | |
| 80 mM | 0.0283 mL | 0.1414 mL | 0.2829 mL | 0.7071 mL | |
| 100 mM | 0.0226 mL | 0.1131 mL | 0.2263 mL | 0.5657 mL |
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