Cymserine
Cymserine is a blood-brain barrier-permeable butyrylcholinesterase (BuChE) inhibitor with an IC50 value of 56.43 nM and a Ki of 38 nM. Cymserine binds to the catalytic domain of BuChE in a concentration-dependent manner to form a stable carbamylated enzyme complex, and exhibits BuChE selectivity over acetylcholinesterase due to its structural compatibility with the larger acyl-binding pocket of BuChE. Cymserine can be used in the research of Alzheimer's disease.
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- CAS 番号: 145209-39-8
- 分子式: C23H29N3O2
- 分子量:379.50
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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BuChE 38 nM (Ki) |
Cymserine (0.02-0.12 μM; 0-60 min) potently inhibits purified human BuChE with an IC50 range of 63-100 nM (depending on substrate concentration), a minimum IC50 of 56.43 nM, and a Ki of 38 nM, and exhibits time-dependent binding activity loss with a critical 50% activity loss time of 7.54 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 145209-39-8
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分子量 379.50
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分子式 C23H29N3O2
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SMILES
C[C@]12C3=CC(OC(NC4=CC=C(C=C4)C(C)C)=O)=CC=C3N([C@@]1([H])N(CC2)C)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Cymserine 関連分類
HY-182615 関連分類
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