Demoxepam
Based on 1 Customer Validation
Demoxepam is a major metabolite of Chlordiazepoxide. Demoxepam exhibits cytotoxicity activity against cancer cell lines. Demoxepam has anticonvulsant and anxiolytic effects. Demoxepam has an inhibitory effect on in vitro [3H]tryptophan binding to rat hepatic nuclei.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.5%
- CAS 番号: 963-39-3
- 分子式: C15H11ClN2O2
- 分子量:286.71
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Demoxepam (230 μM, 2-48 h) exihibits a cytotoxicity effect against P388 leukemia and B16 melanoma cell lines[1].
Demoxepam (10-12-10-4 M, 2 h) inhibits [3H]tryptophan binding to rat hepatic nuclei[3].
Demoxepam (25 μL, 40 min) displays comparable affinity for rat GABAA benzodiazepine binding sites labeled by 3H-flunitrazepam[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 963-39-3
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性状 Solid
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分子量 286.71
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分子式 C15H11ClN2O2
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Color Light yellow to yellow
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SMILES
O=C1NC2=CC=C(Cl)C=C2C(C3=CC=CC=C3)=[N+]([O-])C1
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別名
デモキセパム
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
純度とドキュメンテーション
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データシート (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Moustapha Ouédraogo, et al. In vitro cytotoxicity study of oxaziridines generated after chlordiazepoxide, demoxepam, and desmethylchlordiazepoxide UV irradiation. Drug Chem Toxicol. 2009;32(4):417-23. [Content Brief]
[2]. Gregory G Sarris, et al. Demoxepam Derivatization and GC-MS Analysis Produces Erroneous Nordiazepam and Oxazepam Results. J Anal Toxicol. 2019 Jun 1;43(5):406-410. [Content Brief]
[3]. Sidransky, H., et al., (1992). Inhibitory effect of demoxepam on tryptophan binding to rat hepatic nuclei. Biochemical medicine and metabolic biology, 47(3), 270–273. [Content Brief]
[4]. Vinkers, C. H., et al., (2010). The rapid hydrolysis of chlordiazepoxide to demoxepam may affect the outcome of chronic osmotic minipump studies. Psychopharmacology, 208(4), 555–562. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Demoxepam 関連分類
HY-136591 関連分類
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