Dimercaprol
Based on 1 publication(s) in Google Scholar
Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent, which exhibits anti-HIV activity. Dimercaprol can be used for the study for arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.01%
- CAS 番号: 59-52-9
- 分子式: C3H8OS2
- 分子量:124.23
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保管条件:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Dimercaprol
More
生物活性
HIV[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
50.1 μM
Compound: Dimercaprol
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Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis
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[PMID: 20966043] |
Dimercaprol (10-100 μM; 4 h) could significantly protect PC-12 cells from Acrolein-mediated cell death in a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC-12 cells
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Concentration:10, 25, 50 and 100 μM
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Incubation Time:4 h
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Result:Significantly protected PC-12 cells from Acrolein-mediated cell death in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (13 days old) injected with HgCl2[3]
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Dosage:12.5 mg/kg, 25 mg/kg, 50 mg/kg or 75 mg/kg
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Administration:Subcutaneous injection; once
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Result:Decreased the mercury contents in liver and kidney.
化学情報
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CAS 番号 59-52-9
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性状 Liquid (Density: 1.239 g/cm3)
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分子量 124.23
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分子式 C3H8OS2
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Color Colorless to light yellow
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SMILES
OCC(S)CS
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別名
2,3-Dimercapto-1-propanol; Dithioglycerol; 2,3-ジメルカプト-1-プロパノール
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Antioxidants (Basel)
Dimercaprol Reprograms Intestinal Redox Homeostasis and Organelle Crosstalk to Combat Iron-Induced Gut Dysbiosis Through NRF2/HO-1 Signaling. [Abstract]2026 Mar 11;15(3):356. PMID: 41897502
溶剤 & 溶解度
DMSO : 50 mg/mL (402.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 16.67 mg/mL (134.19 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (804.96 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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データシート (270 KB)
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SDS (481 KB)
- English - EN (481 KB)
- Français - FR (481 KB)
- Deutsch - DE (481 KB)
- Norwegian - NO (481 KB)
- Español - ES (481 KB)
- Swedish - SV (481 KB)
- Italian - IT (481 KB)
- Korean - KR (481 KB)
- Portuguese - PT (481 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Kubota S, et al. 2,3 Dimercapto-1-propanol inhibits HIV-1 tat activity, viral production, and infectivity in vitro. AIDS Res Hum Retroviruses. 1990 Jul;6(7):919-27. [Content Brief]
[2]. Ran Tian, et al. Dimercaprol is an acrolein scavenger that mitigates acrolein-mediated PC-12 cells toxicity and reduces acrolein in rat following spinal cord injury. J Neurochem. 2017 Jun;141(5):708-720. [Content Brief]
[3]. Taciane Roza, et al. 2,3-Dimercapto-1-propanol does not alter the porphobilinogen synthase inhibition but decreases the mercury content in liver and kidney of suckling rats exposed to HgCl2. Basic Clin Pharmacol Toxicol. 2005 Apr;96(4):302-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 8.0496 mL | 40.2479 mL | 80.4959 mL | 201.2396 mL |
| 5 mM | 1.6099 mL | 8.0496 mL | 16.0992 mL | 40.2479 mL | |
| 10 mM | 0.8050 mL | 4.0248 mL | 8.0496 mL | 20.1240 mL | |
| 15 mM | 0.5366 mL | 2.6832 mL | 5.3664 mL | 13.4160 mL | |
| 20 mM | 0.4025 mL | 2.0124 mL | 4.0248 mL | 10.0620 mL | |
| 25 mM | 0.3220 mL | 1.6099 mL | 3.2198 mL | 8.0496 mL | |
| 30 mM | 0.2683 mL | 1.3416 mL | 2.6832 mL | 6.7080 mL | |
| 40 mM | 0.2012 mL | 1.0062 mL | 2.0124 mL | 5.0310 mL | |
| 50 mM | 0.1610 mL | 0.8050 mL | 1.6099 mL | 4.0248 mL | |
| 60 mM | 0.1342 mL | 0.6708 mL | 1.3416 mL | 3.3540 mL | |
| 80 mM | 0.1006 mL | 0.5031 mL | 1.0062 mL | 2.5155 mL | |
| 100 mM | 0.0805 mL | 0.4025 mL | 0.8050 mL | 2.0124 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Dimercaprol 関連分類
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