DOPE (GMP Like)
DOPE (GMP Like) is the GMP Like class DOPE (HY-112005), and can be used as pharmaceutical excipients. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOPE is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 4004-05-1
- 分子式: C41H78NO8P
- 分子量:744.03
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-112005
DOPEFerroptosis Inhibitor -
HY-113424A
1,2-Dioleoyl-sn-glycero-3-phosphocholinePhospholipid -
HY-W040193
DSPCLiposome Compound -
HY-112005G
DOPE (GMP)Ferroptosis Inhibitor -
HY-130463
POPG sodiumPhospholipid -
HY-112530
1,2-Distearoyl-sn-glycero-3-phosphorylethanolaminePhosphoethanolamine (PE) Lipid -
HY-22274
DMPG sodiumBiochemical Assay Reagent -
HY-141571
DOPG sodiumBiochemical Assay Reagent -
HY-109541
Colfosceril miristatePhospholipid Compound -
HY-109506
DPPCEndogenous Metabolite -
HY-130462
1-Palmitoyl-2-oleoyl-sn-glycero-3-PCSaturated Monobasic Alcohol -
HY-141613
1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodiumPhosphoserine/Phosphatidylserine Ubstitute
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
体外実験
In this study, each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent)[1].With the neutral lipid for the LNP is DOPE, LNP exerts knock-down (KD) effecton macrophages and DCs and Liposome-containing DOPE shows fusogenicity[1].LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells[1].LNP has the potential to be an efficient siRNA delivery system not only for murine but also for human macrophages and DCs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 4004-05-1
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分子量 744.03
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分子式 C41H78NO8P
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SMILES
O=P(OC[C@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)(OCCN)O
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別名
Dioleoylphosphatidylethanolamine (GMP Like); 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (GMP Like)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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RNA interference technology
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing gene transcription or activating RNA degradation. This mechanism was discovered in plants in 1998 by Andrew Fire and Craig Mello. Today, this phenomenon can be observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DOPE (GMP Like) 関連分類
HY-112005GL 関連分類
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