DS-8895
Based on 1 Customer Validation
DS-8895(DS-8895A) is an anti-EphA2 monoclonal antibody with specific binding to EphA2 receptors and EphA2-expressing cells. DS-8895, when conjugated with 89Zr, 111In, or 125I, supports molecular imaging of EphA2 expression in xenograft models. DS-8895 allows noninvasive measurement of EphA2 expresssion in tumors in vivo..
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.19%
- 分子量:147.20 kDa
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
Human IgG1 kappa
Human
|
EPHA2 |
DS-8895 (10 μg/mL) confirms high EphA2 expression on MDA-MB-231 human breast carcinoma cells via flow cytometry[2].
DS-8895 (Radiolabeled 125I-DS-8895a, 111In-CHX-A″-DTPA-DS-8895a, 89Zr-Df-Bz-NCS-DS-8895a) exhibit high radiochemical purity, specific immunoreactivity with MDA-MB-231 cells, and measurable EphA2 binding affinity and site density[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:athymic BALB/c nu/nu (5-6 week old female)[2]
-
Dosage:0.25 mg/kg
-
Administration:i.v.; single dose
-
Result:Reached tumor uptake of 7.58 %ID/g at day 2 and 6.73 %ID/g at day 7 for 89Zr-Df-Bz-NCS-DS-8895a.
Showed significantly lower uptake than in EphA2-positive MDA-MB-231 xenografts at the same time points (21.52 %ID/g and 23.64 %ID/g, respectively; P<0.0001).
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
Product Image
ELISA, FACS, Functional assay
化学情報
-
性状 Liquid
-
分子量 147.20 kDa
-
Color Colorless to light yellow
-
SMILES
N/A
-
別名
DS-8895A
-
輸送条件
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
-
データシート (260 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
参考文献
[1]. Giorgio C, et al. Ephrin or not? Six tough questions on Eph targeting. Expert Opin Ther Targets. 2020;24(5):403-415. [Content Brief]
[2]. Burvenich IJ, et al. Molecular Imaging and Quantitation of EphA2 Expression in Xenograft Models with 89Zr-DS-8895a. J Nucl Med. 2016;57(6):974-980. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DS-8895 関連分類
HY-P991577 関連分類
Powered by Bioz