DS01080522
DS01080522 is a Protein Kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor. DS01080522 inhibits PRKACA kinase activity and CREB phosphorylation with IC50s of 0.8 nM and 66 nM, respectively. DS01080522 can be used for the research of cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2832159-84-7
- 分子式: C23H20Cl2N4O3
- 分子量:471.34
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 0.8 nM (PRKACA kinase), 66 nM (CREB phosphorylation)[1]
DS01080522 (1-10 μM; 30 min) affects phosphorylation of CREB[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NIH/3T3 cells
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Concentration:1-10 μM
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Incubation Time:30 min
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Result:Dose-dependently decreased the phosphorylation level of CREB which is a marker of intracellular PRAKACA inhibitory activity in NIH/3T3 cells with an IC50 value of 66 nM.
化学情報
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CAS 番号 2832159-84-7
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分子量 471.34
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分子式 C23H20Cl2N4O3
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SMILES
O=C(N[C@H]([C@@]1([H])C[C@H](O)CN1)C2=CC(Cl)=C(C#N)C=C2)C3=CC4=CC=NC(Cl)=C4C=C3OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DS01080522 関連分類
HY-150073 関連分類
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