EBI-907
EBI-907 is an orally active and highly potent B-RafV600E inhibitor. EBI-907 demonstrates excellent A375 and Colo-205 cellular antiproliferative activity with IC50 values of 13 nM and 14 nM, respectively. EBI-907 can also cause tumor regression in a B-RafV600E-dependent Colo-205 tumor xenograft model of mice. EBI-907 is promising for research of melanoma and B-RafV600E associated cancers.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1581764-31-9
- 分子式: C23H21ClF2N4O3S
- 分子量:506.95
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
13 nM
Compound: 13g; EBI-907
|
Growth inhibition of human A375 cells
Growth inhibition of human A375 cells
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[PMID: 26739779] |
| Calu-6 | IC50 |
455 nM
Compound: 13g; EBI-907
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Growth inhibition of human Calu6 cells carrying a wild-type B-Raf
Growth inhibition of human Calu6 cells carrying a wild-type B-Raf
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[PMID: 26739779] |
| COLO 205 | IC50 |
14 nM
Compound: 13g; EBI-907
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Growth inhibition of human COLO205 cells
Growth inhibition of human COLO205 cells
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[PMID: 26739779] |
化学情報
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CAS 番号 1581764-31-9
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分子量 506.95
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分子式 C23H21ClF2N4O3S
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SMILES
O=S(NC1=CC=C(C(C2=CC3=CNC4=NN=C(C5CC5)C4=C3C=C2OC)=C1Cl)F)(CCCF)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Lu B, et al. Discovery of EBI-907: A highly potent and orally active B-Raf(V600E) inhibitor for the treatment of melanoma and associated cancers. Bioorg Med Chem Lett. 2016 Feb 1;26(3):819-823. [Content Brief]
[2]. Zhang J, et al. EBI-907, a novel BRAF(V600E) inhibitor, has potent oral anti-tumor activity and a broad kinase selectivity profile. Cancer Biol Ther. 2016;17(2):199-207. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
EBI-907 関連分類
HY-117707 関連分類
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