F2F-202

F2F-202 (25-400 μM; 24 h) alone does not significantly inhibit the growth of azole-sensitive Candida albicans ATCC 90028, but when applied at concentrations of 100-400 μM for 24 h, it causes a moderate concentration-dependent reduction (12-26%) in the growth of azole-resistant Candida albicans ATCC 10231^[1].
F2F-202 (100 μM; 1-6 days) exerts a synergistic effect with Voriconazole (FICI = 0.129), completely inhibiting the long-term (6-day) growth of azole-resistant C. albicans ATCC 10231 and abrogating the trailing effect of azole-susceptible C. albicans ATCC 90028^[1].
F2F-202 (100 μM; 2-24 h) alone does not inhibit yeast-hypha transition of Candida albicans ATCC 10231, but when combined with Voriconazole, it significantly reduces hypha formation and promotes the maintenance of yeast morphology after 24 h of treatment at 37 °C^[1].
F2F-202 (100 μM; 2-24 h) regulates the expression of genes associated with virulence, stress response and azole resistance in Candida albicans ATCC 10231; its efficacy is enhanced when used in combination with Voriconazole, including significant down-regulation of Als1 and Hwp1 expression, as well as inhibition of Voriconazole-induced up-regulation of Erg11^[1].
F2F-202 (100 μM; 24 h) alone does not induce intracellular ROS production in Candida albicans ATCC 10231, but when combined with Voriconazole, it significantly enhances Voriconazole-induced oxidative stress after 24 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.