FY-21
FY-21 is a selective inhibitor of LSD1 (IC50=340 nM), with anti-proliferation and anti-colony formation activities. FY-21 enhances p53 expression, down-regulates HOXA9 and MEIS1 expression. FY-21 also induces leukemia cell differentiation to exhibts antitumor activity.
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- CAS 番号: 3049681-20-8
- 分子式: C17H15F3N2O6
- 分子量:400.31
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 340 nM (LSD1)[1]
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-13 | IC50 |
83 μM
Compound: 3k; FY-21
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Cytotoxicity against human MOLM-13 cells incubated for 7 days by CCK8 assay
Cytotoxicity against human MOLM-13 cells incubated for 7 days by CCK8 assay
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[PMID: 37257211] |
| MV4-11 | IC50 |
42 μM
Compound: 3k; FY-21
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Cytotoxicity against human MV4-11 cells incubated for 7 days by CCK8 assay
Cytotoxicity against human MV4-11 cells incubated for 7 days by CCK8 assay
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[PMID: 37257211] |
化学情報
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CAS 番号 3049681-20-8
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分子量 400.31
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分子式 C17H15F3N2O6
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SMILES
OC1=C(C=C2C(NCCC2=C1)C3=CC=C(C=C3)[N+]([O-])=O)O.FC(C(O)=O)(F)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
FY-21 関連分類
HY-155526 関連分類
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