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ANP32B - acidic nuclear phosphoprotein 32 family member B Gene

Also Known as APRIL; SSP29; PHAPI2

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 10541

About ANP32B

Cytogenetic location: 9q22.33 Genomic coordinates (GRCh38): 9:97,983,341-98,015,943 (from NCBI)

This gene has 3 transcripts (splice variants), 302 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 88.8), lymph node (RPKM 73.8) and 25 other tissues.

Summary

Enables RNA polymerase binding activity and histone binding activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; nucleosome assembly; and positive regulation of protein export from nucleus. Located in cytoplasm and nucleoplasm. Colocalizes with nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

ANP32B Products (1)

mRNA	Protein	Name
NM_006401.3	NP_006392.1	acidic leucine-rich nuclear phosphoprotein 32 family member B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables RNA polymerase binding	IDA IDA: Inferred from direct assay	9285060	GOA
enables histone binding	IDA IDA: Inferred from direct assay	20538007	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	20015864	GOA
involved in negative regulation of cell differentiation	IDA IDA: Inferred from direct assay	22705300	GOA
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	20538007	GOA
involved in positive regulation of protein export from nucleus	IMP IMP: Inferred from mutant phenotype	17178712	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cytoplasm	IDA IDA: Inferred from direct assay	17178712	GOA
colocalizes with nucleolus	IDA IDA: Inferred from direct assay	9285060	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9285060	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANP32B Protein Structure

LRR_9

0
100
200
251 a.a.

Protein Preferred Names	Protein Names
acidic leucine-rich nuclear phosphoprotein 32 family member B	acidic (leucine-rich) nuclear phosphoprotein 32 family, member B

ANP32B Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	ANP32B	Q92688	BEND7	Homo sapiens	Q8N7W2-2	Y2H Prey Pooling	32296183
Intra	ANP32B	Q92688	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	32296183
Intra	ANP32B	Q92688	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	ANP32B	Q92688	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	ANP32B	Q92688	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	ANP32B	Q92688	YAF2	Homo sapiens	Q8IY57-5	Y2H Array	32296183
Intra	ANP32B	Q92688	YAF2	Homo sapiens	Q8IY57-5	Y2H Prey Pooling	32296183
Intra	ANP32B	Q92688	FAM217B	Homo sapiens	Q9NTX9	Validated Y2H	32296183
Intra	ANP32B	Q92688	FAM217B	Homo sapiens	Q9NTX9	Y2H Prey Pooling	32296183
Intra	ANP32B	Q92688	FAM217B	Homo sapiens	Q9NTX9	Y2H Array	32296183
Intra	ANP32B	Q92688	DNTTIP1	Homo sapiens	Q9H147	Validated Y2H	32296183
Intra	ANP32B	Q92688	DNTTIP1	Homo sapiens	Q9H147	Y2H Array	32296183
Intra	ANP32B	Q92688	DNTTIP1	Homo sapiens	Q9H147	Y2H Prey Pooling	32296183
Intra	ANP32B	Q92688	MYNN	Homo sapiens	Q9NPC7	Y2H Prey Pooling	32296183
Intra	ANP32B	Q92688	MYNN	Homo sapiens	Q9NPC7	Validated Y2H	32296183
Intra	ANP32B	Q92688	MYNN	Homo sapiens	Q9NPC7	Y2H Array	32296183
Intra	ANP32B	Q92688	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	ANP32B	Q92688	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	ANP32B	Q92688	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	ANP32B	Q92688	KPNA1	Homo sapiens	P52294	Y2H Prey Pooling	32296183
Intra	ANP32B	Q92688	KPNA1	Homo sapiens	P52294	Y2H Array	25416956
Intra	ANP32B	Q92688	KPNA1	Homo sapiens	P52294	Y2H Array	32296183
Intra	ANP32B	Q92688	KPNA6	Homo sapiens	O60684	Y2H Array	32296183
Intra	ANP32B	Q92688	KPNA6	Homo sapiens	O60684	Y2H Prey Pooling	32296183
Intra	ANP32B	Q92688	KPNA5	Homo sapiens	O15131	Y2H Prey Pooling	32296183
Intra	ANP32B	Q92688	KPNA5	Homo sapiens	O15131	Y2H Array	31515488
Intra	ANP32B	Q92688	KPNA5	Homo sapiens	O15131	Y2H Array	32296183
Intra	ANP32B	Q92688	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	ANP32B	Q92688	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	ANP32B	Q92688	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	ANP32B	Q92688	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
Intra	ANP32B	Q92688	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
Intra	ANP32B	Q92688	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

ANP32B 抗体

製品番号	製品名	アプリケーション	反応性
HY-P81865	PHAPI2/APRIL Antibody (YA1610)	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
HY-P81865A	PHAPI2/APRIL Antibody (YA1610)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
HY-P82513	PHAPI2/APRIL Antibody (YA2258)	WB, ICC/IF	Human, Mouse, Rat

Diseases	Alias
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Myopathy, Congenital, Compton-North	Compton-North Congenital Myopathy MYPCN Congenital Lethal Myopathy, Compton-North Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-184486	ANDS		/	Unkown
HY-RS00752	ANP32B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	ANP32B	VGNC	VGNC:59835
Rattus norvegicus	ANP32B	RGD	RGD:621285
Macaca mulatta	ANP32B	VGNC	VGNC:103240
Canis familiaris	ANP32B	VGNC	VGNC:37933
Bos taurus	ANP32B	VGNC	VGNC:25958
Mus musculus	ANP32B	MGD	MGI:1914878
Others	ANP32B	NCBI