ESRRA - estrogen related receptor alpha Gene

Also Known as ERR1; ERRa; ESRL1; NR3B1; ERRalpha

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 2101

About ESRRA

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,305,524-64,316,743 (from NCBI)

This gene has 8 transcripts (splice variants), 168 orthologues and 8 paralogues. Ubiquitous expression in duodenum (RPKM 26.2), kidney (RPKM 21.8) and 24 other tissues.

Summary

The protein encoded by this gene is a nuclear receptor that is most closely related to the Estrogen receptor. This protein acts as a site-specific transcription factor and interacts with members of the PGC-1 family of transcription cofactors to regulate the expression of most genes involved in cellular energy production as well as in the process of mitochondrial biogenesis. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq, Jun 2019]

ESRRA Products (6)

mRNA	Protein	Name
NM_004451.5	NP_004442.3	steroid hormone receptor ERR1 isoform 1
NM_001282450.2	NP_001269379.1	steroid hormone receptor ERR1 isoform 1
NM_001282451.2	NP_001269380.1	steroid hormone receptor ERR1 isoform 2
XM_047426523.1	XP_047282479.1	steroid hormone receptor ERR1 isoform X2
XM_047426524.1	XP_047282480.1	steroid hormone receptor ERR1 isoform X3
XM_017017313.2	XP_016872802.1	steroid hormone receptor ERR1 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	21190936	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12522104	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	11984006	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23836911	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	23836911	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cytoplasm	IDA IDA: Inferred from direct assay	21190936	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21190936	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ESRRA Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
423 a.a.

Protein Preferred Names	Protein Names
steroid hormone receptor ERR1	ERR-alpha estrogen receptor-like 1 estrogen-related nuclear receptor alpha nuclear receptor subfamily 3 group B member 1

ESRRA Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	ESRRA	P11474	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
Intra	ESRRA	P11474	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	ESRRA	P11474	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	ESRRA	P11474	ESRRG	Homo sapiens	P62508-3	Y2H Prey Pooling	32296183
Intra	ESRRA	P11474	ESRRG	Homo sapiens	P62508-3	Validated Y2H	32296183
Intra	ESRRA	P11474	ESRRG	Homo sapiens	P62508-3	Y2H Array	32296183
Intra	ESRRA	P11474	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	ESRRA	P11474	RNF4	Homo sapiens	P78317	Validated Y2H	32296183
Intra	ESRRA	P11474	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	ESRRA	P11474	HIF1A	Homo sapiens	Q16665	Pull Down	18509053
Intra	ESRRA	P11474	HIF1A	Homo sapiens	Q16665	Anti Bait CoIP	18509053
Intra	ESRRA	P11474	PIAS4	Homo sapiens	Q8N2W9	Anti Tag CoIP	18063693
Intra	ESRRA	P11474	PPARGC1A	Homo sapiens	Q9UBK2	DSC	15337744
Intra	ESRRA	P11474	PPARGC1A	Homo sapiens	Q9UBK2	Y2H Prey Pooling	32296183
Intra	ESRRA	P11474	PPARGC1A	Homo sapiens	Q9UBK2	FPS	15337744
Intra	ESRRA	P11474	PPARGC1A	Homo sapiens	Q9UBK2	X-Ray Diffraction	18441008
Intra	ESRRA	P11474	PPARGC1A	Homo sapiens	Q9UBK2	Pull Down	18063693
Intra	ESRRA	P11474	PPARGC1A	Homo sapiens	Q9UBK2	X-Ray Diffraction	15337744
Intra	ESRRA	P11474	PPARGC1A	Homo sapiens	Q9UBK2	Gal4 VP16 Complement	18441008
Intra	ESRRA	P11474	PPARGC1A	Homo sapiens	Q9UBK2	Y2H	12522104
Intra	ESRRA	P11474	PPARGC1A	Homo sapiens	Q9UBK2	Validated Y2H	32296183
Intra	ESRRA	P11474	PPARGC1A	Homo sapiens	Q9UBK2	Y2H Array	32296183
Intra	ESRRA	P11474	TNNI2	Homo sapiens	P48788	Validated Y2H	32296183
Intra	ESRRA	P11474	TNNI2	Homo sapiens	P48788	Y2H Array	32296183
Intra	ESRRA	P11474	TNNI2	Homo sapiens	P48788	Y2H Prey Pooling	32296183
Intra	ESRRA	P11474	FAM9A	Homo sapiens	Q8IZU1	Validated Y2H	32296183
Intra	ESRRA	P11474	FAM9A	Homo sapiens	Q8IZU1	Y2H Prey Pooling	32296183
Intra	ESRRA	P11474	FAM9A	Homo sapiens	Q8IZU1	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

ESRRA 抗体

製品番号	製品名	アプリケーション	反応性
HY-P82538	ERR alpha Antibody (YA2283)	WB, IP, FC	Human, Mouse, Rat
HY-P84064	ERR alpha Antibody (YA3761)	WB, FC, ELISA	Human, Rat
HY-P84064A	ERR alpha Antibody (YA3761)(PBS only)	WB, FC, ELISA	Human, Rat

関連疾患

Diseases	Alias
Amelogenesis Imperfecta, Type Ig	Enamel-Renal Syndrome Ers Amelogenesis Imperfecta Type 1g AI1G Enamel-Renal-Gingival Syndrome Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome Aigfs Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis Amelogenesis Imperfecta Type Ig Amelogenesis Imperfecta-Nephrocalcinosis Syndrome Amelogenesis Imperfecta 1g Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis Amelogenesis Imperfecta Nephrocalcinosis
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
3-Methylglutaconic Aciduria, Type Iii	Optic Atrophy 3-Methylglutaconic Aciduria Type 3 Costeff Syndrome Mga3 Costeff Optic Atrophy Syndrome Optic Atrophy Plus Syndrome Infantile Optic Atrophy With Chorea And Spastic Paraplegia 3-Methylglutaconic Aciduria Type Iii Autosomal Recessive Optic Atrophy Plus Syndrome Autosomal Recessive Optic Atrophy Type 3 Opa3 Defect MGCA3 Mga, Type Iii Iraqi Jewish Optic Atrophy Plus Mga Type Iii Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia Iraqi-Jewish 'Optic Atrophy Plus' Optic Atrophy 3, Autosomal Recessive Opa3, Autosomal Recessive Opa3-Related 3-Methylglutaconic Aciduria Iraqi-Jewish Optic Atrophy Plus Atrophy Of Optic Disc 3-Alpha Methylglutaconic Aciduria Type Iii Optic Atrophy 3 Optic Atrophy Infantile With Chorea And Spastic Paraplegia Autosomal Recessive Opa3 Autosomal Recessive Optic Atrophy 3 3-Methylglutaconic Aciduria 3 3-Alpha-Methylglutaconic Aciduria Type 3 Optic Atrophy 3 Autosomal Recessive Atrophy, Optic Atrophy, Optic, Plus Syndrome Optic Nerve Atrophy Primary Optic Atrophy Oa - [Optic Atrophy] Second Cranial Nerve Atrophy Second Cranium Nerve Atrophy
Teeth Hard Tissue Disease
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS04537	ESRRA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04538	Esrra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04539	Esrra Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	ESRRA	VGNC	VGNC:61967
Mus musculus	ESRRA	MGD	MGI:1346831
Macaca mulatta	ESRRA	VGNC	VGNC:100926
Rattus norvegicus	ESRRA	RGD	RGD:1583866
Bos taurus	ESRRA	VGNC	VGNC:28608
Canis familiaris	ESRRA	VGNC	VGNC:54270
Others	ESRRA	NCBI