GPR3 - G protein-coupled receptor 3 Gene

Also Known as ACCA

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 2827

About GPR3

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:27,392,622-27,395,814 (from NCBI)

This gene has 1 transcript (splice variant), 183 orthologues and 18 paralogues. Broad expression in brain (RPKM 2.0), thyroid (RPKM 0.6) and 17 other tissues.

Summary

This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates Adenylate Cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]

GPR3 Products (1)

mRNA	Protein	Name
NM_005281.4	NP_005272.1	G-protein coupled receptor 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	24069330	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR3 Protein Structure

7tm_1

0
100
200
300
330 a.a.

Protein Preferred Names	Protein Names
G-protein coupled receptor 3	ACCA orphan receptor

GPR3 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	GPR3	P46089	APP	Homo sapiens	P05067-4	Anti Tag CoIP	24069330

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Pituitary Adenoma 2, Growth Hormone-Secreting	PITA2 Acromegaly Due To Pituitary Adenoma 2 Acromegaly, X-Linked Growth Hormone Secreting Pituitary Adenoma 2 Pituitary Adenoma, Growth Hormone-Secreting, 2 Pituitary Adenoma 2, Gh-Secreting Gh-Secreting Pituitary Adenoma 2 X-Linked Acromegaly Adenoma, Pituitary, Growth Hormone-Secreting, Type 2
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Lennox-Gastaut Syndrome	Lennox Syndrome Encephalopathy Of Childhood Epileptic Encephalopathy Lennox-Gastaut Type Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves Lgs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Phase
HY-108496	Sphingosine-1-phosphate	Agonist	99.94%	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-12664	AF64394	Inhibitor	98.02%	Unkown
HY-155318A	GPR3 agonist-2	Agonist	99.90%	Unkown
HY-108496S	Sphingosine-1-phosphate-d7	Agonist	99.9%	Unkown
HY-182011	GPR6 inverse agonist 2	Agonist	/	Unkown
HY-183657A	GPR3 inverse agonist-1 TFA		/	Unkown
HY-RS05700	GPR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17955	Gpr3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24426	Gpr3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	GPR3	RGD	RGD:628686
Mus musculus	GPR3	MGD	MGI:101908
Bos taurus	GPR3	VGNC	VGNC:29581
Canis familiaris	GPR3	VGNC	VGNC:41429
Macaca mulatta	GPR3	VGNC	VGNC:73131
Felis catus	GPR3	VGNC	VGNC:67423
Others	GPR3	NCBI