HDAC7 - histone deacetylase 7 Gene

Also Known as HD7; HD7A; HDAC7A

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 51564

About HDAC7

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:47,782,722-47,821,344 (from NCBI)

This gene has 30 transcripts (splice variants), 263 orthologues and 10 paralogues. Ubiquitous expression in lung (RPKM 18.9), spleen (RPKM 18.4) and 25 other tissues.

Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

HDAC7 Products (18)

mRNA Protein Name
NR_160435.1
NM_001368046.1 NP_001354975.1 histone deacetylase 7 isoform f
XM_047428983.1 XP_047284939.1 histone deacetylase 7 isoform X9
XM_011538483.1 XP_011536785.1 histone deacetylase 7 isoform X10
NM_001308090.2 NP_001295019.1 histone deacetylase 7 isoform e
XM_047428981.1 XP_047284937.1 histone deacetylase 7 isoform X7
XM_011538481.2 XP_011536783.2 histone deacetylase 7 isoform X1
XM_047428978.1 XP_047284934.1 histone deacetylase 7 isoform X2
NR_160436.1
NM_015401.5 NP_056216.2 histone deacetylase 7 isoform a
XM_047428979.1 XP_047284935.1 histone deacetylase 7 isoform X5
XM_024449018.2 XP_024304786.1 histone deacetylase 7 isoform X3
XM_047428982.1 XP_047284938.1 histone deacetylase 7 isoform X8
XM_047428984.1 XP_047284940.1 histone deacetylase 7 isoform X8
NM_016596.3
XM_011538480.1 XP_011536782.1 histone deacetylase 7 isoform X4
NM_001098416.4 NP_001091886.1 histone deacetylase 7 isoform d
XM_047428980.1 XP_047284936.1 histone deacetylase 7 isoform X6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables 14-3-3 protein binding IDA
IDA: Inferred from direct assay
16980613 GOA
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
17360565 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15161933 GOA
enables protein kinase C binding IPI
IPI: Inferred from physical interaction
20188095 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16980613 GOA
enables protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
30538141 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in negative regulation of interleukin-2 production IDA
IDA: Inferred from direct assay
17360565 GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
25411248 GOA
involved in negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
17997710 GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
19351956 GOA
involved in protein deacetylation IMP
IMP: Inferred from mutant phenotype
30538141 GOA
involved in regulation of mRNA processing IDA
IDA: Inferred from direct assay
37369679 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
16980613 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16980613 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDAC7 Protein Structure

Hist_deacetyl

Hist_deacetyl: Histone deacetylase domain (534 - 859)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 952 a.a.
Protein Preferred Names Protein Names

histone deacetylase 7

  • histone deacetylase 7A

HDAC7 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
HDAC7 Q8WUI4 PRKD2 Homo sapiens Q9BZL6
Anti Tag CoIP
17962809
Intra
HDAC7 Q8WUI4 PRKD2 Homo sapiens Q9BZL6
Anti Bait CoIP
17962809
Intra
HDAC7 Q8WUI4 FOXP3 Homo sapiens Q9BZS1-2
Anti Tag CoIP
17360565
Intra
HDAC7 Q8WUI4 EGFR Homo sapiens P00533
Lumier
24658140
Intra
HDAC7 Q8WUI4 YWHAZ Homo sapiens P63104
Anti Tag CoIP
33961781
Intra
HDAC7 Q8WUI4 YWHAZ Homo sapiens P63104
CoIP
20224040
Intra
HDAC7 Q8WUI4 YWHAZ Homo sapiens P63104
Pull Down
15161933
Intra
HDAC7 Q8WUI4 YWHAZ Homo sapiens P63104
Anti Tag CoIP
23752268
Intra
HDAC7 Q8WUI4 SFN Homo sapiens P31947
TAP
15778465
Intra
HDAC7 Q8WUI4 SFN Homo sapiens P31947
Anti Tag CoIP
18339811
Intra
HDAC7 Q8WUI4 SFN Homo sapiens P31947
Anti Tag CoIP
23752268
Intra
HDAC7 Q8WUI4 FOXP3 Homo sapiens Q9BZS1-1
Anti Tag CoIP
17360565
Cross: Cross-species interaction Intra: Intraspecies interaction

HDAC7 抗体

製品番号 製品名 アプリケーション 反応性
HY-P83401 HDAC7 Antibody (YA3146) WB, FC Human, Mouse, Rat

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-10221 Vorinostat Inhibitor 99.96% Yes
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes

Clinical Phase

Bioactive Molecules (6)
製品番号 製品名 製品効果
純度 Phase
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1
HY-15994 Citarinostat Inhibitor 99.55% Phase 1

Pre-clinical Phase

Bioactive Molecules (43)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-18361 TMP195 Inhibitor 99.82% Unkown
HY-13428 Tubacin Inhibitor 97.11% Unkown
HY-N6735 Apicidin Inhibitor 99.87% Unkown
HY-18360 TMP269 Inhibitor 98.16% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-119939 CHDI-390576 Inhibitor 98.10% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-126330 SS-208 Inhibitor 99.00% Unkown
HY-N5084 Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside Inhibitor 98.92% Unkown
HY-169259 HDAC9-IN-1 Inhibitor 95.13% Unkown
HY-150109 Purinostat mesylate Inhibitor 99.45% Unkown
HY-135714 Bavarostat Inhibitor 99.51% Unkown
HY-149285 NT160 Inhibitor 99.58% Unkown
HY-148624 CHDI-00484077 Inhibitor 98.38% Unkown
HY-149208 HDAC-IN-53 Inhibitor 95.73% Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-162319 Tubulin/HDAC-IN-4 Inhibitor / Unkown
HY-184574 HDAC-IN-104 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-180224 HDAC6-IN-70 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-159172 HDAC3-IN-4 Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-162630 HDAC6-IN-44 Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-180811 ALK/HDAC-IN-2 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-178104 HDAC-IN-93 Inhibitor / Unkown
HY-150774 HDAC6/HSP90-IN-2 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-179227 HDAC6 ligand-7 Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris HDAC7 VGNC VGNC:49112
Bos taurus HDAC7 VGNC VGNC:49060
Mus musculus HDAC7 MGD MGI:1891835
Rattus norvegicus HDAC7 RGD RGD:619982
Macaca mulatta HDAC7 VGNC VGNC:99939
Felis catus HDAC7 VGNC VGNC:62770
Others HDAC7 NCBI