SLAMF7 - SLAM family member 7 Gene

Also Known as 19A; CS1; CD319; CRACC

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 57823

About SLAMF7

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:160,739,057-160,754,821 (from NCBI)

This gene has 11 transcripts (splice variants), 138 orthologues and 9 paralogues. Biased expression in lymph node (RPKM 22.3), appendix (RPKM 19.3) and 13 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in adaptive immune response. Predicted to act upstream of or within regulation of natural killer cell activation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

SLAMF7 Products (10)

mRNA Protein Name
NM_001282588.2 NP_001269517.1 SLAM family member 7 isoform b precursor
NM_001282589.2 NP_001269518.1 SLAM family member 7 isoform c precursor
NM_001282590.2 NP_001269519.1 SLAM family member 7 isoform d
NM_001282591.2 NP_001269520.1 SLAM family member 7 isoform e
NM_001282592.2 NP_001269521.1 SLAM family member 7 isoform f precursor
NM_001282593.2 NP_001269522.1 SLAM family member 7 isoform g
NM_001282594.2 NP_001269523.1 SLAM family member 7 isoform h
NM_001282595.1 NP_001269524.1 SLAM family member 7 isoform i
NM_001282596.2 NP_001269525.1 SLAM family member 7 isoform j
NM_021181.5 NP_067004.3 SLAM family member 7 isoform a precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables identical protein binding IPI
IPI: Inferred from physical interaction
15153464 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLAMF7 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (23 - 124)

Ig_3

Ig_3: Immunoglobulin domain (130 - 199)

  • 0
  • 100
  • 200
  • 300
  • 335 a.a.
Protein Preferred Names Protein Names

SLAM family member 7

  • 19A24 protein

SLAMF7 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
SLAMF7 Q9NQ25 SLAMF7 Homo sapiens Q9NQ25
FACS
15153464
Intra
SLAMF7 Q9NQ25 MAK Homo sapiens P20794
Y2H Array
21988832
Intra
SLAMF7 Q9NQ25 CMTM6 Homo sapiens Q9NX76
Anti Tag CoIP
33961781
Intra
SLAMF7 Q9NQ25 PTCD2 Homo sapiens Q8WV60
Anti Tag CoIP
33961781
Intra
SLAMF7 Q9NQ25 SLAMF7 Homo sapiens Q9NQ25
Protein Array
21982860
Intra
SLAMF7 Q9NQ25 NCR3 Homo sapiens O14931
FACS
15153464
Intra
SLAMF7 Q9NQ25 SH2D1B Homo sapiens O14796
SPR
24642916
Intra
SLAMF7 Q9NQ25 TBC1D23 Homo sapiens Q9NUY8
Anti Tag CoIP
33961781
Intra
SLAMF7 Q9NQ25 CLK3 Homo sapiens P49761
Y2H Array
21988832
Intra
SLAMF7 Q9NQ25 HUS1 Homo sapiens O60921
Anti Tag CoIP
33961781
Intra
SLAMF7 Q9NQ25 TNFSF9 Homo sapiens P41273
Anti Tag CoIP
33961781
Intra
SLAMF7 Q9NQ25 CTNNB1 Homo sapiens P35222
Anti Tag CoIP
33961781
Intra
SLAMF7 Q9NQ25 YIF1A Homo sapiens O95070
Anti Tag CoIP
33961781
Intra
SLAMF7 Q9NQ25 FBXO2 Homo sapiens Q9UK22
Anti Tag CoIP
33961781
Intra
SLAMF7 Q9NQ25 SH2D1A Homo sapiens O60880
SPR
24642916
Intra
SLAMF7 Q9NQ25 NAGPA Homo sapiens Q9UK23
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SLAMF7 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P72416 CRACC/SLAMF7 Protein, Human (Biotinylated, HEK293, His-Avi) Q9NQ25-1 (S23-M226) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72460 CRACC/SLAMF7 Protein, Human (HEK293, His) Q9NQ25-1 (S23-M226) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77202 CRACC/SLAMF7 Protein, Human (HEK293, hFc) Q9NQ25-1 (S23-M226) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P77203 CRACC/SLAMF7 Protein, Human (Biotinylated, HEK293, Fc) Q9NQ25-1 (S23-M226) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P77205 CRACC/SLAMF7 Protein, Human (Biotinylated, HEK293, His) Q9NQ25-1 (S23-M226) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78517 CRACC/SLAMF7 Protein, Human (HEK293, mFc) Q9NQ25-1 (S23-M226) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78518 CRACC/SLAMF7 Protein, Human (HEK293, His-Avi) Q9NQ25-1 (S23-M226) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78642 FITC-Labeled CRACC/SLAMF7 Protein, Human (HEK293, His) Q9NQ25-1 (S23-M226) ≥ 90%, as determined by reducing SDS-PAGE.

SLAMF7 抗体

製品番号 製品名 アプリケーション 反応性
HY-P81432 SLAMF7/CS1 Antibody (YA1177) IHC-P Human
HY-P81432A SLAMF7/CS1 Antibody (YA1177)(PBS only) IHC-P Human
HY-P81747 SLAMF7/CS1 Antibody (YA1492) FC, ELISA Human
HY-P84817 SLAMF7/CS1 Antibody (YA4514) WB, IHC-P, FC, ELISA Human, Mouse, Rat, Monkey, Rabbit
HY-P84817A SLAMF7/CS1 Antibody (YA4514)(PBS only) WB, IHC-P, FC, ELISA Human, Mouse, Rat, Monkey, Rabbit

関連疾患

Diseases Alias
Plasmablastic Lymphoma

  • Pbl

  • Immunoblastic Large-Cell Lymphoma
Smoldering Myeloma
Lupus Erythematosus

  • Lupus

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus, Systemic

  • Subacute Cutaneous Lupus

  • Le - [Lupus Erythematosus]
Intellectual Developmental Disorder, Autosomal Dominant 10

  • MRD10

  • Mental Retardation, Autosomal Dominant 10

  • Autosomal Dominant Non-Syndromic Intellectual Disability 10

  • Autosomal Dominant Intellectual Developmental Disorder 10

  • Autosomal Dominant Mental Retardation 10

  • Mental Retardation, Autosomal Dominant, Type 10
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Monoclonal Gammopathy Of Uncertain Significance

  • Monoclonal Gammopathy Of Undetermined Significance

  • Mgus

  • Mgus - [Monoclonal Gammopathy Of Undetermined Significance]

  • Monoclonal Gammopathy Nos

  • Iga Gammopathy

  • Monoclonal Gammoglobulinopathy
Igg4-Related Disease

  • Multifocal Fibrosclerosis

  • Igg4-Related Sclerosing Disease

  • Igg4-Related Systemic Disease

  • Immunoglobulin G4-Related Sclerosing Disease

  • Hyper-Igg4 Disease

  • Igg4-Associated Disease

  • Igg4-Positive Multiorgan Lymphoproliferative Syndrome

  • Igg4-Related Autoimmune Disease

  • Igg4-Related Systemic Sclerosing Disease

  • Igg4-Syndrome

  • Multifocal Idiopathic Fibrosclerosis

  • Systemic Igg4-Related Plasmacytic Syndrome

  • Systemic Igg4-Related Sclerosing Syndrome

  • Mediastinal Fibrosis, Familial

  • Retroperitoneal Fibrosis, Familial

  • Igg4-Rd
Non-Secretory Myeloma
Blood Protein Disease

  • Blood Protein Disorders

  • Blood Protein Disorder
Plasma Cell Leukemia

  • Plasma Cell Leukaemia

  • Leukemia, Plasma Cell

  • Plasmacytic Leukaemia

  • Plasmacytic Leukemia

  • Pcl

  • Plasma Cell Leukaemia, Nos

  • Leukemic Plasma Cell

  • Plasma Cell Leukaemia Without Mention Of Remission
Bone Marrow Cancer

  • Malignant Neoplasm Of Bone Marrow

  • Bone Marrow Neoplasm

  • Bone Marrow Tumor

  • Malignant Bone Marrow Tumor

  • Myeloproliferative Disorders

  • Bone Marrow Neoplasms

  • Myeloproliferative Disease

  • Chronic Myeloproliferative Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

阻害性抗体 (1)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-P9965 Elotuzumab Inhibitor 99.9% Unkown

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS12981 SLAMF7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16919 Slamf7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23362 Slamf7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
阻害性抗体 (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P99453 Azintuxizumab ≥99.0% Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus SLAMF7 VGNC VGNC:34655
Canis familiaris SLAMF7 VGNC VGNC:46208
Mus musculus SLAMF7 MGD MGI:1922595
Macaca mulatta SLAMF7 VGNC VGNC:77547
Rattus norvegicus SLAMF7 RGD RGD:1560190
Felis catus SLAMF7 VGNC VGNC:107940
Others SLAMF7 NCBI