CCL20 - C-C motif chemokine ligand 20 Gene

Also Known as CKb4; LARC; ST38; MIP3A; Exodus; MIP-3a; SCYA20; MIP-3-alpha

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 6364

About CCL20

Cytogenetic location: 2q36.3 Genomic coordinates (GRCh38): 2:227,813,842-227,817,556 (from NCBI)

This gene has 5 transcripts (splice variants), 86 orthologues and 25 paralogues. Biased expression in gall bladder (RPKM 83.4), urinary bladder (RPKM 31.6) and 7 other tissues.

Summary

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

CCL20 Products (2)

mRNA	Protein	Name
NM_001130046.2	NP_001123518.1	C-C motif chemokine 20 isoform 2 precursor
NM_004591.3	NP_004582.1	C-C motif chemokine 20 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	参考文献	由来
enables CCR6 chemokine receptor binding	IDA IDA: Inferred from direct assay	12081481	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17703191	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12949249	GOA
involved in calcium-mediated signaling	IDA IDA: Inferred from direct assay	25122636	GOA
involved in cell chemotaxis	IDA IDA: Inferred from direct assay	23765988	GOA
involved in chemotaxis	IDA IDA: Inferred from direct assay	20068036	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	12949249	GOA
acts upstream of or within positive regulation of T cell migration	IDA IDA: Inferred from direct assay	23620790	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL20 Protein Structure

IL8

0
96 a.a.

Protein Preferred Names	Protein Names
C-C motif chemokine 20	CC chemokine LARC

CCL20 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	CCL20	P78556	PF4	Homo sapiens	P02776	SPR	28381538
Intra	CCL20	P78556	PF4	Homo sapiens	P02776	Filter Binding	28381538
Intra	CCL20	P78556	CCL5	Homo sapiens	P13501	Filter Binding	28381538
Intra	CCL20	P78556	CCL5	Homo sapiens	P13501	SPR	28381538
Intra	CCL20	P78556	CXCL12	Homo sapiens	P48061	Filter Binding	28381538
Intra	CCL20	P78556	CXCL12	Homo sapiens	P48061	SPR	28381538
Intra	CCL20	P78556	RALBP1	Homo sapiens	Q15311	Anti Tag CoIP	17703191

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCL20 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P7260	MIP-3 alpha/CCL20 Protein, Human (CHO)	P78556-1 (A27-M96)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7262	MIP-3 alpha/CCL20 Protein, Human	P78556-1 (A27-M96)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73814	MIP-3 alpha/CCL20 Protein, Human (His)	P78556-1 (A27-M96)	≥ 90%, as determined by reducing SDS-PAGE.

関連疾患

Diseases	Alias
Sialadenitis	Sialoadenitis Adenitis, Salivary Gland Salivary Gland Inflammation Salivary Gland Adenitis Sialitis Inflammation Of Salivary Gland Inflammation Of Salivary Duct Or Gland Salivary Glandular Adenitis Sialoangiitis Sialoangitis Sialodochitis
Trichomoniasis	Trichomonas Infection Trichomonas Infections Disease Due To Trichomonadidae Infection By Trichomonas Trichomonadosis Trichomonas Pruritus Trichomonosis Tricomoniasis
Psoriasis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Colitis
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Periarthritis
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Autoimmune Disease Of Skin And Connective Tissue
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Vaginal Disease	Vaginal Diseases
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Pulmonary Disease, Chronic Obstructive	Chronic Obstructive Pulmonary Disease COPD Pulmonary Disease, Chronic Obstructive, Severe Early-Onset Chronic Obstructive Lung Disease Chronic Obstructive Airway Disease Pulmonary Disease, Chronic Obstructive, Susceptibility To Cold Severe Early-Onset Chronic Obstructive Pulmonary Disease Pulmonary Disease Chronic Obstructive Pulmonary Disease, Obstructive, Chronic, Susceptibility To Chronic Obstructive Pulmonary Disease Of Horses Common Cold Upper Respiratory Infections Copd - [Chronic Obstructive Pulmonary Disease] Coad - [Chronic Obstructive Airways Disease] Cold - [Chronic Obstructive Lung Disease] Chronic Airway Disease Nos Chronic Airways Limitation, Unspecified Chronic Obstructed Airway, Unspecified Chronic Obstructive Airway Disease, Unspecified Chronic Obstructive Airway, Unspecified Obstructive Lung Disease Nos Chronic Obstructive Lung Disease Nos Chronic Obstructive Lung Nos Obstructive Pulmonary Disease Nos Exacerbation Copd Nos Acute Exacerbation Copd
Silo Filler'S Disease	Silo Filler Disease Silo-Fillers' Disease
Psoriasis 11	PSORS11 Psoriasis Susceptibility 11 Psoriasis Psoriasis Vulgaris Psoriasis 11, Susceptibility To Pv
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

阻害性抗体 (1)

製品番号	製品名	製品効果	純度	Phase
HY-P990592	GSK-3050002		97.30%	Phase 1

Pre-clinical Phase

Bioactive Molecules (10)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-151435	CCR6 antagonist 1	Antagonist	99.30%	Unkown
HY-19548A	BEC hydrochloride	Inhibitor	98.0%	Unkown
HY-162495	IDOR-1117-2520		99.94%	Unkown
HY-162495A	(S)-IDOR-1117-2520		99.47%	Unkown
HY-172161	CCR6 antagonist 2	Antagonist	/	Unkown
HY-178053	AHR agonist 10		/	Unkown
HY-RS02090	CCL20 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174762	Human CCL20 mRNA		/	Unkown
HY-RS16609	Ccl20 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23043	Ccl20 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Canis familiaris	CCL20	VGNC	VGNC:38884
Rattus norvegicus	CCL20	RGD	RGD:3646
Mus musculus	CCL20	MGD	MGI:1329031
Macaca mulatta	CCL20	VGNC	VGNC:70699
Felis catus	CCL20	VGNC	VGNC:60542
Bos taurus	CCL20	VGNC	VGNC:26947
Others	CCL20	NCBI