SELPLG - selectin P ligand Gene

Also Known as CLA; CD162; PSGL1; PSGL-1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 6404

About SELPLG

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:108,621,895-108,633,894 (from NCBI)

This gene has 3 transcripts (splice variants) and 72 orthologues. Broad expression in spleen (RPKM 29.0), lymph node (RPKM 26.4) and 22 other tissues.

Summary

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- Selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

SELPLG Products (2)

mRNA Protein Name
NM_001206609.2 NP_001193538.1 P-selectin glycoprotein ligand 1 isoform 1 precursor
NM_003006.4 NP_002997.2 P-selectin glycoprotein ligand 1 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
11081633 GOA
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within cellular response to interleukin-6 IDA
IDA: Inferred from direct assay
9486531 GOA
involved in leukocyte migration IDA
IDA: Inferred from direct assay
25425738 GOA
involved in leukocyte tethering or rolling IDA
IDA: Inferred from direct assay
25425738 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in plasma membrane IDA
IDA: Inferred from direct assay
21696602 GOA
located in plasma membrane raft IDA
IDA: Inferred from direct assay
25425738 GOA
located in uropod IDA
IDA: Inferred from direct assay
21696602 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

P-selectin glycoprotein ligand 1

  • cutaneous lymphocyte-associated associated antigen

SELPLG Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
SELPLG Q14242 SELP Homo sapiens P16109
SPR
19118202
Intra
SELPLG Q14242 SNX20 Homo sapiens Q7Z614
Peptide Array
18196517
Intra
SELPLG Q14242 SNX20 Homo sapiens Q7Z614
Y2H
18196517
Intra
SELPLG Q14242 SNX20 Homo sapiens Q7Z614
Anti Bait CoIP
18196517
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SELPLG Proteins

製品番号 製品名 アクセッション番号 純度
HY-P72485 CD162/PSGL-1 Protein, Human (HEK293, hFc) Q14242-1 (Q42-G295) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77162 CD162/PSGL-1 Protein, Human (HEK293, His-Fc) AAC50061.1 (L18-V295) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77163 CD162/PSGL-1 Protein, Human (HEK293, His) Q14242-1 (L18-G295) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77164 CD162/PSGL-1 Protein, Human (HEK293, mFc) AAC50061.1 (L18-V295) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78819 CD162/PSGL-1 Protein, Human (Biotinylated, HEK293, His-Avi) Q14242-1 (Q42-C320) ≥ 95%, as determined by Bis-Tris PAGE.

SELPLG 抗体

製品番号 製品名 アプリケーション 反応性
HY-P81711 CD162 Antibody (YA1456) WB, IHC-P, ICC/IF, IP Human
HY-P84565 CD162 Antibody (YA4262) IHC-P, FC, ELISA Human
HY-P84565A CD162 Antibody (YA4262)(PBS only) IHC-P, FC, ELISA Human
HY-P84970 CD162 Antibody (YA4662) ELISA Human

関連疾患

Diseases Alias
Human Granulocytic Anaplasmosis

  • Human Granulocytic Ehrlichiosis

  • Hge

  • Human Ehrlichial Infection, Human Granulocytic Type

  • Human Anaplasmosis Due To Anaplasma Phagocytophilum
Ehrlichiosis

  • Human Ehrlichiosis

  • He

  • Hey
Thrombosis

  • Thrombosis Of Blood Vessel
Cerebrovascular Disease

  • Cerebrovascular Disorder

  • Cerebrovascular Accident

  • Cerebrovascular Disorders

  • Cva

  • Stroke
Endocervicitis
Leukocyte Adhesion Deficiency, Type I

  • Leukocyte Adhesion Deficiency

  • Leukocyte Adhesion Deficiency 1

  • LAD1

  • Lad

  • Lymphocyte Function-Associated Antigen 1 Immunodeficiency

  • Leukocyte Adhesion Deficiency Type I

  • Leukocyte Adhesion Deficiency Type 1

  • Linear Iga Bullous Dermatosis

  • Linear Iga Dermatosis

  • Leukocyte-Adhesion Deficiency Syndrome

  • Lfa1 Immunodeficiency

  • Congenital Leukocyte Adherence Deficiency

  • Lad-I

  • Linear Iga Disease

  • Leukocyte Adhesion Deficiency Syndrome

  • Lad 1

  • Lfa 1 Immunodeficiency

  • Linear Immunoglobulin A Dermatosis

  • Leucocyte Adhesion Deficiency Type 1

  • Leukocyte Adhesion Molecule Deficiency Type 1
Colon Carcinoma In Situ

  • Carcinoma In Situ Of Colon

  • Stage 0 Colonic Carcinoma

  • Stage 0 Carcinoma Of Colon

  • Intraepithelial Neoplasia Of Colon, High Grade

  • Carcinoma In Situ Of Cecum

  • Carcinoma In Situ Of Hepatic Flexure

  • Carcinoma In Situ Of Ileocecal Valve

  • Carcinoma In Situ Of Hepatic Flexure Of Colon
Intestine Carcinoma In Situ
Acute Flaccid Myelitis
Multiple Sclerosis

  • MS

  • Multiple Sclerosis, Susceptibility To

  • Disseminated Sclerosis

  • Multiple Sclerosis, Disease Progression, Modifier Of

  • Insular Sclerosis

  • Multiple Sclerosis Modifier Of Disease Progression

  • Multiple Sclerosis, Susceptibility To 1

  • Multiple Sclerosis, Susceptibility To, 1

  • Multiple Sclerosis 1

  • Generalized Multiple Sclerosis

  • Multiple Sclerosis Variant

  • Multiple Sclerosis Susceptibility To

  • Cerebrospinal Sclerosis

  • Generalised Multiple Sclerosis

  • Ms - [Multiple Sclerosis]

  • Disseminated Cerebrospinal Sclerosis

  • Disseminated Multiple Sclerosis

  • Disseminated Nervous System Myelosclerosis

  • Multiple Cerebrospinal Sclerosis

  • Multiple Combined Sclerosis

  • Multiple Sclerosis Generalised

  • Disseminated Brain Sclerosis

  • Disseminated Spinal Sclerosis

  • Insular Brain Sclerosis

  • Miliary Brain Sclerosis

  • Multiple Combined Sclerosis Of Spinal Cord

  • Multiple Ascending Sclerosis

  • Multiple Brain Sclerosis

  • Multiple Sclerosis Of Brain Stem

  • Multiple Sclerosis Of The Brain Stem

  • Multiple Sclerosis Of Cord

  • Sclérose En Plaques

  • Plaque Sclerosis

  • Multiple Sclerosis Of The Spinal Cord
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Aseptic Meningitis

  • Acute Aseptic Meningitis

  • Meningitis Aseptic

  • Meningitis, Aseptic
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS12648 SELPLG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18203 Selplg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24679 Selplg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus SELPLG VGNC VGNC:107723
Macaca mulatta SELPLG VGNC VGNC:77158
Rattus norvegicus SELPLG RGD RGD:1307971
Mus musculus SELPLG MGD MGI:106689
Canis familiaris SELPLG VGNC VGNC:45986
Bos taurus SELPLG VGNC VGNC:34425
Others SELPLG NCBI