SNRPA - small nuclear ribonucleoprotein polypeptide A Gene

Also Known as U1A; Mud1; U1-A

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 6626

About SNRPA

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,751,203-40,765,389 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 22.2), lymph node (RPKM 20.2) and 25 other tissues.

Summary

The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010]

SNRPA Products (1)

mRNA	Protein	Name
NM_004596.5	NP_004587.1	U1 small nuclear ribonucleoprotein A

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables DNA binding	EXP EXP: Inferred from Experiment	8609632	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	19561594	GOA
enables U1 snRNA binding	IDA IDA: Inferred from direct assay	2147232	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9848648	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of U1 snRNP	IDA IDA: Inferred from direct assay	21113136	GOA
part of U1 snRNP	IPI IPI: Inferred from physical interaction	33677607	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: Inferred from physical interaction	30975767	GOA
part of spliceosomal complex	IDA IDA: Inferred from direct assay	9731529	GOA
part of spliceosomal complex	IPI IPI: Inferred from physical interaction	33677607	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRPA Protein Structure

RRM_1

0
100
200
282 a.a.

Protein Preferred Names	Protein Names
U1 small nuclear ribonucleoprotein A	U1 small nuclear RNP-specific A

SNRPA Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	SNRPA	P09012	ENOX2	Homo sapiens	Q16206-2	Y2H Prey Pooling	25416956
Intra	SNRPA	P09012	ENOX2	Homo sapiens	Q16206-2	Y2H Array	25416956
Intra	SNRPA	P09012	NDUFAF3	Homo sapiens	Q9BU61-2	Y2H Prey Pooling	25416956
Intra	SNRPA	P09012	NDUFAF3	Homo sapiens	Q9BU61-2	Y2H Array	25416956
Intra	SNRPA	P09012	METTL13	Homo sapiens	Q8N6R0	Y2H Array	25416956
Intra	SNRPA	P09012	TIAL1	Homo sapiens	Q01085-2	Validated Y2H	32296183
Intra	SNRPA	P09012	U2AF2	Homo sapiens	P26368-2	Validated Y2H	32296183
Intra	SNRPA	P09012	U2AF2	Homo sapiens	P26368-2	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	U2AF2	Homo sapiens	P26368-2	Y2H Array	32296183
Intra	SNRPA	P09012	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	SNRPA	P09012	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	SNRPA	P09012	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	PCBP3	Homo sapiens	P57721-2	Validated Y2H	32296183
Intra	SNRPA	P09012	CHTOP	Homo sapiens	Q9Y3Y2-3	Validated Y2H	32296183
Intra	SNRPA	P09012	CHTOP	Homo sapiens	Q9Y3Y2-3	Y2H Array	32296183
Intra	SNRPA	P09012	CHTOP	Homo sapiens	Q9Y3Y2-3	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	RBPMS2	Homo sapiens	Q6ZRY4	Validated Y2H	32296183
Intra	SNRPA	P09012	RBPMS2	Homo sapiens	Q6ZRY4	Y2H Array	32296183
Intra	SNRPA	P09012	RBPMS2	Homo sapiens	Q6ZRY4	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	RBMY1A1	Homo sapiens	P0DJD3-2	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	RBMY1A1	Homo sapiens	P0DJD3-2	Validated Y2H	32296183
Intra	SNRPA	P09012	RBMY1A1	Homo sapiens	P0DJD3-2	Y2H Array	30886144
Intra	SNRPA	P09012	RBMY1A1	Homo sapiens	P0DJD3-2	Y2H Array	32296183
Intra	SNRPA	P09012	FUBP1	Homo sapiens	Q96AE4-2	Validated Y2H	32296183
Intra	SNRPA	P09012	FUBP1	Homo sapiens	Q96AE4-2	Y2H Array	32296183
Intra	SNRPA	P09012	FUBP1	Homo sapiens	Q96AE4-2	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	PTBP2	Homo sapiens	Q9UKA9-2	Validated Y2H	32296183
Intra	SNRPA	P09012	MBNL2	Homo sapiens	Q5VZF2-2	Validated Y2H	32296183
Intra	SNRPA	P09012	MBNL2	Homo sapiens	Q5VZF2-2	Y2H Array	32296183
Intra	SNRPA	P09012	MBNL2	Homo sapiens	Q5VZF2-2	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	TIA1	Homo sapiens	P31483	Anti Bait CoIP	12486009
Intra	SNRPA	P09012	TIA1	Homo sapiens	P31483	Pull Down	12486009
Intra	SNRPA	P09012	NDUFAF3	Homo sapiens	Q9BU61	Validated Y2H	32296183
Intra	SNRPA	P09012	DAZAP1	Homo sapiens	Q96EP5	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	DAZAP1	Homo sapiens	Q96EP5	Validated Y2H	32296183
Intra	SNRPA	P09012	DAZAP1	Homo sapiens	Q96EP5	Y2H Array	32296183
Intra	SNRPA	P09012	MRPL15	Homo sapiens	Q9P015	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	MRPL15	Homo sapiens	Q9P015	Validated Y2H	32296183
Intra	SNRPA	P09012	MRPL15	Homo sapiens	Q9P015	Y2H Array	32296183
Intra	SNRPA	P09012	LHX4	Homo sapiens	Q969G2	Validated Y2H	32296183
Intra	SNRPA	P09012	LHX4	Homo sapiens	Q969G2	Y2H Array	32296183
Intra	SNRPA	P09012	LHX4	Homo sapiens	Q969G2	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	RBM3	Homo sapiens	P98179	Validated Y2H	25416956
Intra	SNRPA	P09012	RBM3	Homo sapiens	P98179	Validated Y2H	32296183
Intra	SNRPA	P09012	RBM3	Homo sapiens	P98179	Y2H Array	25416956
Intra	SNRPA	P09012	RBM3	Homo sapiens	P98179	Y2H Prey Pooling	25416956
Intra	SNRPA	P09012	RBM3	Homo sapiens	P98179	Y2H Array	29892012
Intra	SNRPA	P09012	HNRNPK	Homo sapiens	P61978	Y2H Prey Pooling	25416956
Intra	SNRPA	P09012	HNRNPK	Homo sapiens	P61978	Validated Y2H	25416956
Intra	SNRPA	P09012	HNRNPK	Homo sapiens	P61978	Anti Tag CoIP	35271311
Intra	SNRPA	P09012	HNRNPK	Homo sapiens	P61978	Y2H Array	25416956
Intra	SNRPA	P09012	RASAL3	Homo sapiens	Q86YV0	Validated Y2H	32296183
Intra	SNRPA	P09012	RASAL3	Homo sapiens	Q86YV0	Y2H Array	32296183
Intra	SNRPA	P09012	RASAL3	Homo sapiens	Q86YV0	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	DDX39B	Homo sapiens	Q13838	Anti Tag CoIP	35271311
Intra	SNRPA	P09012	DDX39B	Homo sapiens	Q13838	Validated Y2H	32296183
Intra	SNRPA	P09012	PTBP1	Homo sapiens	P26599	Y2H Array	31515488
Intra	SNRPA	P09012	PTBP1	Homo sapiens	P26599	Validated Y2H	25416956
Intra	SNRPA	P09012	HNRNPU	Homo sapiens	Q00839	Anti Tag CoIP	35271311
Intra	SNRPA	P09012	HNRNPU	Homo sapiens	Q00839	Crosslink	30021884
Intra	SNRPA	P09012	SFPQ	Homo sapiens	P23246	Anti Tag CoIP	35271311
Intra	SNRPA	P09012	SFPQ	Homo sapiens	P23246	Anti Bait CoIP	9848648
Intra	SNRPA	P09012	CIRBP	Homo sapiens	Q14011	Validated Y2H	25416956
Intra	SNRPA	P09012	CIRBP	Homo sapiens	Q14011	Y2H Prey Pooling	25416956
Intra	SNRPA	P09012	CIRBP	Homo sapiens	Q14011	Y2H Array	25416956
Intra	SNRPA	P09012	SNRPA1	Homo sapiens	P09661	Y2H	22365833
Intra	SNRPA	P09012	SNRPA1	Homo sapiens	P09661	Anti Tag CoIP	35271311
Intra	SNRPA	P09012	SNRPA1	Homo sapiens	P09661	Validated Y2H	32296183
Intra	SNRPA	P09012	SNRPA1	Homo sapiens	P09661	Validated Y2H	25416956
Intra	SNRPA	P09012	GABPB1	Homo sapiens	Q06547	Y2H Array	25416956
Intra	SNRPA	P09012	HNRNPK	Homo sapiens	P61978-2	Validated Y2H	32296183
Intra	SNRPA	P09012	RBM4B	Homo sapiens	Q9BQ04	Validated Y2H	32296183
Intra	SNRPA	P09012	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	SNRPA	P09012	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	SNRPA	P09012	TRIM27	Homo sapiens	P14373	Validated Y2H	32296183
Intra	SNRPA	P09012	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	LENG8	Homo sapiens	Q96PV6	Validated Y2H	32296183
Intra	SNRPA	P09012	LENG8	Homo sapiens	Q96PV6	Y2H Prey Pooling	25416956
Intra	SNRPA	P09012	LENG8	Homo sapiens	Q96PV6	Anti Tag CoIP	35271311
Intra	SNRPA	P09012	LENG8	Homo sapiens	Q96PV6	Validated Y2H	25416956
Intra	SNRPA	P09012	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	SNRPA	P09012	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	SNRPA	P09012	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	RBM11	Homo sapiens	P57052	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	RBM11	Homo sapiens	P57052	Validated Y2H	32296183
Intra	SNRPA	P09012	RBM11	Homo sapiens	P57052	Y2H Array	32296183
Intra	SNRPA	P09012	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	SNRPA	P09012	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	SNRPA	P09012	U2AF2	Homo sapiens	P26368	Anti Tag CoIP	22365833
Intra	SNRPA	P09012	U2AF2	Homo sapiens	P26368	Validated Y2H	25416956
Intra	SNRPA	P09012	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	SNRPA	P09012	RBMX	Homo sapiens	P38159	Y2H Prey Pooling	25416956
Intra	SNRPA	P09012	RBMX	Homo sapiens	P38159	Anti Tag CoIP	35271311
Intra	SNRPA	P09012	TRIR	Homo sapiens	Q9BQ61	Validated Y2H	32296183
Intra	SNRPA	P09012	TRIR	Homo sapiens	Q9BQ61	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	TRIR	Homo sapiens	Q9BQ61	Y2H Array	32296183
Intra	SNRPA	P09012	TRIR	Homo sapiens	Q9BQ61	Y2H	22365833
Intra	SNRPA	P09012	TRIR	Homo sapiens	Q9BQ61	Y2H Pooling	16189514
Intra	SNRPA	P09012	TNFAIP8L1	Homo sapiens	Q8WVP5	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	TNFAIP8L1	Homo sapiens	Q8WVP5	Validated Y2H	32296183
Intra	SNRPA	P09012	TNFAIP8L1	Homo sapiens	Q8WVP5	Y2H Array	32296183
Intra	SNRPA	P09012	CD2BP2	Homo sapiens	O95400	Anti Tag CoIP	35271311
Intra	SNRPA	P09012	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	RBMY1F	Homo sapiens	Q15415	Validated Y2H	32296183
Intra	SNRPA	P09012	RBMY1F	Homo sapiens	Q15415	Y2H Array	32296183
Intra	SNRPA	P09012	OTX2	Homo sapiens	P32243-2	Y2H Array	32296183
Intra	SNRPA	P09012	OTX2	Homo sapiens	P32243-2	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	OTX2	Homo sapiens	P32243-2	Validated Y2H	32296183
Intra	SNRPA	P09012	QKI	Homo sapiens	Q96PU8	Validated Y2H	25416956
Intra	SNRPA	P09012	QKI	Homo sapiens	Q96PU8	Y2H Prey Pooling	25416956
Intra	SNRPA	P09012	PCBP2	Homo sapiens	Q15366	Y2H Prey Pooling	25416956
Intra	SNRPA	P09012	PCBP2	Homo sapiens	Q15366	Y2H Array	25416956
Intra	SNRPA	P09012	PCBP1	Homo sapiens	Q15365	Validated Y2H	25416956
Intra	SNRPA	P09012	PCBP1	Homo sapiens	Q15365	Validated Y2H	32296183
Intra	SNRPA	P09012	PCBP1	Homo sapiens	Q15365	Y2H Prey Pooling	25416956
Intra	SNRPA	P09012	GIGYF1	Homo sapiens	O75420	Y2H Array	32296183
Intra	SNRPA	P09012	GIGYF1	Homo sapiens	O75420	Y2H Prey Pooling	32296183
Intra	SNRPA	P09012	ZCCHC13	Homo sapiens	Q8WW36	Validated Y2H	32296183
Intra	SNRPA	P09012	ZCCHC13	Homo sapiens	Q8WW36	Y2H Array	32296183
Intra	SNRPA	P09012	ZCCHC13	Homo sapiens	Q8WW36	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

SNRPA 抗体

製品番号	製品名	アプリケーション	反応性
HY-P82015	U1A Antibody (YA1760)	WB, ICC/IF, IP	Human, Mouse, Rat

Diseases	Alias
Mixed Connective Tissue Disease	Sharp Syndrome Mctd Connective Tissue Disease Overlap Syndrome Mixed Collagen Vascular Disease Mctd - [Mixed Connective Tissue Disease]
Premature Ovarian Failure 18	POF18 Primary Ovarian Insufficiency 18 Ovarian Failure, Premature, Type 18
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Mucopolysaccharidosis, Type Iiia	Mucopolysaccharidosis Type Iiia MPS3A Mps Iiia Sanfilippo Syndrome A Heparan Sulfate Sulfatase Deficiency Sulfamidase Deficiency Heparan Sulfamidase Deficiency Mpsiiia Mucopolysaccharidosis Type 3a Sanfilippo Syndrome Type A Mucopolysaccharidosis Iii-A Heparane Sulfamidase Deficiency Mps 3a Mucopoly-Saccharidosis Type 3a Mps Iii-A Mucopolysaccharidosis 3a Mucopolysaccharidosis Iii
Mucopolysaccharidosis Iii	Sanfilippo Syndrome Mucopolysaccharidosis Type Iii Mucopolysaccharidosis Type 3 Mps Iii Mpsiii Sanfilippo Disease Heparan Sulfate Sulfatase Deficiency Mucopolysaccharidosis, Mps-Iii N-Sulphoglucosamine Sulphohydrolase Deficiency Naglu Deficiency Sanfilippo'S Syndrome Mucopoly-Saccharidosis Type 3 Mps3 Sanfilippos Syndrome Mucopolysaccharidosis Type Iiia Mps Iii B

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS13500	SNRPA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13501	SNRPA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19482	Snrpa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	SNRPA	VGNC	VGNC:97639
Macaca mulatta	SNRPA	VGNC	VGNC:77674
Bos taurus	SNRPA	VGNC	VGNC:35074
Mus musculus	SNRPA	MGD	MGI:1855690
Rattus norvegicus	SNRPA	RGD	RGD:1307416
Others	SNRPA	NCBI