PSCA - prostate stem cell antigen Gene

Also Known as PRO232; lncPSCA

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 8000

About PSCA

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:142,670,297-142,682,725 (from NCBI)

This gene has 4 transcripts (splice variants), 93 orthologues and 2 paralogues. Biased expression in stomach (RPKM 721.2), urinary bladder (RPKM 108.9) and 1 other tissue.

Summary

This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

PSCA Products (1)

mRNA Protein Name
NM_005672.5 NP_005663.2 prostate stem cell antigen preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables acetylcholine receptor binding IDA
IDA: Inferred from direct assay
25680266 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
25680266 GOA
involved in regulation of neurotransmitter receptor activity IDA
IDA: Inferred from direct assay
25680266 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSCA Protein Structure

UPAR_LY6

UPAR_LY6: u-PAR/Ly-6 domain (14 - 84)

  • 0
  • 100
  • 114 a.a.
Protein Preferred Names Protein Names

prostate stem cell antigen

Recombinant PSCA Proteins

製品番号 製品名 アクセッション番号 純度
HY-P78013 PSCA Protein, Human (HEK293, Fc) O43653 (L12-S86) ≥ 95%, as determined by Bis-Tris PAGE.

PSCA 抗体

製品番号 製品名 アプリケーション 反応性
HY-P81734 PSCA Antibody (YA1479) IHC-P, FC, ELISA Human
HY-P83846 PSCA Antibody (YA3543) ICC/IF, FC, ELISA Human
HY-P83846A PSCA Antibody (YA3543)(PBS only) ICC/IF, FC, ELISA Human
HY-P85819 PSCA Antibody (YA5511) WB, ICC/IF, ELISA Human

関連疾患

Diseases Alias
Transitional Cell Carcinoma

  • Transitional Cell Neoplasm

  • Carcinoma, Transitional Cell

  • Transitional Carcinoma

  • Transitional Cell Tumor

  • Urothelial Cell Carcinoma

  • Carcinoma Transitional Cell

  • Transitional Cell Carcinoma Of Bladder
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Duodenal Ulcer

  • Stress Ulcer

  • Curling Ulcer

  • Stress Ulcer Of Stomach

  • Curling'S Ulcers

  • Duodenal Ulcer Disease

  • Duodenal Ulcers

  • Duodenal Peptic Ulcer
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Cardia Cancer

  • Ca Cardia - Stomach

  • Malignant Neoplasm Of Cardia Of Stomach
Colloid Carcinoma Of The Pancreas
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Diffuse Gastric Cancer

  • Hereditary Diffuse Gastric Adenocarcinoma

  • Hereditary Diffuse Gastric Cancer

  • Signet Cell Adenocarcinoma

  • Signet Ring Cell Carcinoma

  • Signet Ring Cell Gastric Carcinoma

  • Signet Ring Gastric Carcinoma

  • Fdgc

  • Familial Diffuse Cancer Of Stomach

  • Familial Diffuse Gastric Cancer

  • Gastric Cancer, Familial Diffuse

  • Gastric Cancer, Hereditary Diffuse

  • Hdgc

  • Hereditary Diffuse Cancer Of Stomach

  • Diffuse Gastric Cancer Syndrome

  • Cancer, Gastric, Diffuse

  • Carcinoma, Signet Ring Cell

  • Gastric Signet Ring Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS11271 PSCA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-168943C PLGA nanoparticles, 1μm / Unkown
HY-RS17893 Psca Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24362 Psca Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
阻害性抗体 (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P990319 ALT-100 (Human IgG4) Inhibitor ≥99.0% Unkown
HY-P991075 ALT-100 (Human IgG1) Inhibitor 99.90% Unkown
HY-P991229 MK-4721 96.66% Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus PSCA MGD MGI:1919623
Rattus norvegicus PSCA RGD RGD:1594221
Macaca mulatta PSCA VGNC VGNC:99472
Canis familiaris PSCA VGNC VGNC:56075
Others PSCA NCBI