AKAP17A - A-kinase anchoring protein 17A Gene

Also Known as XE7; 721P; XE7Y; CCDC133; CXYorf3; PRKA17A; SFRS17A; AKAP-17A; DXYS155E

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 8227

About AKAP17A

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:1,591,604-1,602,520 (from NCBI)

This gene has 3 transcripts (splice variants) and 183 orthologues. Ubiquitous expression in spleen (RPKM 26.3), bone marrow (RPKM 23.0) and 25 other tissues.

Summary

This locus encodes a protein kinase A anchoring protein. The encoded protein is part of the spliceosome complex and is involved in the regulation of alternate splicing in some mRNA precursors. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Sep 2010]

AKAP17A Products (1)

mRNA Protein Name
NM_005088.3 NP_005079.2 A-kinase anchor protein 17A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
16982639 GOA
enables protein kinase A binding IDA
IDA: Inferred from direct assay
19840947 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in regulation of RNA splicing IMP
IMP: Inferred from mutant phenotype
19840947 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in nuclear speck IDA
IDA: Inferred from direct assay
16982639 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19840947 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A-kinase anchor protein 17A

  • A kinase (PRKA) anchor protein 17A

AKAP17A Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
AKAP17A Q02040 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
AKAP17A Q02040 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra
AKAP17A Q02040 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
AKAP17A Q02040 ZRANB2 Homo sapiens O95218
Anti Tag CoIP
16982639
Intra
AKAP17A Q02040 ZRANB2 Homo sapiens O95218
IF
16982639
Intra
AKAP17A Q02040 ZRANB2 Homo sapiens O95218
Y2H
16982639
Intra
AKAP17A Q02040 ANKRD36B Homo sapiens Q8N2N9-4
Validated Y2H
32296183
Intra
AKAP17A Q02040 ANKRD36B Homo sapiens Q8N2N9-4
Y2H Prey Pooling
32296183
Intra
AKAP17A Q02040 ANKRD36B Homo sapiens Q8N2N9-4
Y2H Array
32296183
Intra
AKAP17A Q02040 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra
AKAP17A Q02040 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra
AKAP17A Q02040 HMGXB4 Homo sapiens Q9UGU5
Validated Y2H
32296183
Intra
AKAP17A Q02040 HMGXB4 Homo sapiens Q9UGU5
Y2H Array
32296183
Intra
AKAP17A Q02040 HMGXB4 Homo sapiens Q9UGU5
Y2H Prey Pooling
32296183
Intra
AKAP17A Q02040 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
AKAP17A Q02040 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
25416956
Intra
AKAP17A Q02040 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
AKAP17A Q02040 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
25416956
Intra
AKAP17A Q02040 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra
AKAP17A Q02040 DVL3 Homo sapiens Q92997
Validated Y2H
32296183
Intra
AKAP17A Q02040 DVL3 Homo sapiens Q92997
Y2H Array
32296183
Intra
AKAP17A Q02040 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
Intra
AKAP17A Q02040 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
32296183
Intra
AKAP17A Q02040 THAP1 Homo sapiens Q9NVV9
Validated Y2H
32296183
Intra
AKAP17A Q02040 THAP1 Homo sapiens Q9NVV9
Y2H Array
32296183
Intra
AKAP17A Q02040 SDCBP2 Homo sapiens Q9H190
Validated Y2H
32296183
Intra
AKAP17A Q02040 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
32296183
Intra
AKAP17A Q02040 SDCBP2 Homo sapiens Q9H190
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Null-Cell Leukemia

  • Null Cell Acute Lymphoblastic Leukemia

  • Null Cell Acute Lymphoblastic Leukaemia

  • Null-Cell Leukaemia
Corneal Dystrophy, Posterior Polymorphous, 2

  • Posterior Polymorphous Corneal Dystrophy 2

  • PPCD2

  • Corneal Dystrophy, Posterior Polymorphous 2

  • Corneal Dystrophy Polymorphous Posterior, 2

  • Dystrophy, Corneal, Posterior Polymorphous, Type 2
Hodgkin'S Lymphoma, Mixed Cellularity

  • Hodgkin'S Disease, Mixed Cellularity

  • Hodgkins Lymphoma, Mixed Cellularity

  • Mixed Cellularity Hodgkin Lymphoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS00517 AKAP17A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus AKAP17A RGD RGD:1564640
Macaca mulatta AKAP17A VGNC VGNC:69633
Mus musculus AKAP17A MGD MGI:2443758
Bos taurus AKAP17A VGNC VGNC:106636
Others AKAP17A NCBI