PDLIM7 - PDZ and LIM domain 7 Gene

Also Known as LMP1; LMP3

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 9260

About PDLIM7

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,483,394-177,497,604 (from NCBI)

This gene has 16 transcripts (splice variants), 198 orthologues and 7 paralogues. Broad expression in endometrium (RPKM 61.1), prostate (RPKM 52.9) and 22 other tissues.

Summary

The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of RET/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

PDLIM7 Products (3)

mRNA Protein Name
NM_005451.5 NP_005442.2 PDZ and LIM domain protein 7 isoform 1
NM_203352.3 NP_976227.1 PDZ and LIM domain protein 7 isoform 2
NM_213636.3 NP_998801.1 PDZ and LIM domain protein 7 isoform 4

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in adherens junction IDA
IDA: Inferred from direct assay
25468996 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDLIM7 Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (9 - 80)

LIM

LIM: LIM domain (282 - 333)

LIM

LIM: LIM domain (341 - 396)

LIM

LIM: LIM domain (400 - 454)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 457 a.a.
Protein Preferred Names Protein Names

PDZ and LIM domain protein 7

  • 1110003B01Rik

PDLIM7 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
PDLIM7 Q9NR12 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra
PDLIM7 Q9NR12 GPATCH2L Homo sapiens Q9NWQ4-1
Validated Y2H
32296183
Intra
PDLIM7 Q9NR12 TSG101 Homo sapiens Q99816
Anti Tag CoIP
28514442
Intra
PDLIM7 Q9NR12 TSG101 Homo sapiens Q99816
Y2H Prey Pooling
25416956
Intra
PDLIM7 Q9NR12 TSG101 Homo sapiens Q99816
Y2H Array
25416956
Cross
PDLIM7 Q9NR12 Hoxa1 Mus musculus P09022
Y2H
23088713
Cross
PDLIM7 Q9NR12 Hoxa1 Mus musculus P09022
BiFC
23088713
Intra
PDLIM7 Q9NR12 PHF1 Homo sapiens O43189
Y2H Array
31515488
Intra
PDLIM7 Q9NR12 UBQLN4 Homo sapiens Q9NRR5
Y2H Array
16713569
Intra
PDLIM7 Q9NR12 HSPB7 Homo sapiens Q9UBY9
Validated Y2H
32296183
Intra
PDLIM7 Q9NR12 TCF19 Homo sapiens Q9Y242
Validated Y2H
32296183
Intra
PDLIM7 Q9NR12 WWP2 Homo sapiens O00308
Validated Y2H
25416956
Intra
PDLIM7 Q9NR12 WWP2 Homo sapiens O00308
Y2H Array
29892012
Intra
PDLIM7 Q9NR12 WWP2 Homo sapiens O00308
Y2H Pooling
16189514
Intra
PDLIM7 Q9NR12 WWP2 Homo sapiens O00308
Y2H Array
31515488
Intra
PDLIM7 Q9NR12 ENKD1 Homo sapiens Q9H0I2
Y2H Pooling
16189514
Intra
PDLIM7 Q9NR12 GEM Homo sapiens P55040
Y2H Array
31515488
Intra
PDLIM7 Q9NR12 BAG3 Homo sapiens O95817
Anti Tag CoIP
33961781
Intra
PDLIM7 Q9NR12 BAG3 Homo sapiens O95817
Anti Tag CoIP
28514442
Intra
PDLIM7 Q9NR12 HEY2 Homo sapiens Q9UBP5
Validated Y2H
32296183
Intra
PDLIM7 Q9NR12 IQGAP1 Homo sapiens A4QPB0
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

PDLIM7 抗体

製品番号 製品名 アプリケーション 反応性
HY-P81821 PDLIM7 Antibody (YA1566) WB Human
HY-P81821A PDLIM7 Antibody (YA1566)(PBS only) WB Human
HY-P84821 PDLIM7 Antibody (YA4518) IHC-P, ICC/IF, FC, ELISA Human
HY-P84821A PDLIM7 Antibody (YA4518)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

関連疾患

Diseases Alias
Endobronchial Leiomyoma
Larynx Squamous Papilloma

  • Laryngeal Squamous Cell Papilloma
Lymphoepithelioma-Like Carcinoma

  • Lymphoepithelial Carcinoma

  • Nasopharyngeal Type Undifferentiated Carcinoma
Lung Leiomyoma

  • Pulmonary Leiomyoma

  • Leiomyoma Of Lung
Pleural Empyema

  • Empyema

  • Pyothorax

  • Empyema, Pleural

  • Abscess Of Pleural Cavity

  • Abscess Of Thorax

  • Empyema Of Pleura

  • Empyema Of Pleura Without Fistula

  • Empyema With Fistula

  • Empyema With No Fistula

  • Empyema With Pleural Fistula

  • Empyema Without Mention Of Fistula

  • Empyema, Chest

  • Lung Empyema

  • Pleural Empyema With Fistula

  • Pleural Empyema With No Fistula

  • Purulent Pleurisy

  • Purulent Pleuritis

  • Thorax Abscess

  • Pyopneumothorax
Oral Hairy Leukoplakia

  • Hairy Leukoplakia

  • Leukoplakia, Hairy

  • Hairy Leucoplakia
Pfeiffer Syndrome

  • Infectious Mononucleosis

  • Acs5

  • Craniofacial-Skeletal-Dermatologic Dysplasia

  • Acs V

  • Noack Syndrome

  • Gammaherpesviral Mononucleosis

  • Acrocephalosyndactyly Type 5

  • Pfeiffer Syndrome Type 3

  • Acrocephalosyndactyly, Type V

  • Glandular Fever

  • Pfeiffer Type Acrocephalosyndactyly

  • Pfeiffer Syndrome Type 2

  • Acrocephalosyndactylia Type V

  • Filatov'S Disease

  • Monocytic Angina

  • Mononucleosis

  • Pfeiffer'S Disease

  • Acsv

  • Acrocephalosyndactyly, Type 5

  • Craniofacial-Skeletal-Dermatologic Syndrome

  • Pfeiffer Syndrome Type 1

  • Classic Pfeiffer Syndrome

  • PS

  • Pfeiffer Syndrome Variant

  • Dysplasia, Craniofacial-Skeletal-Dermatologic

  • Pfeiffer

  • Kissing Disease

  • Infectious Adenitis

  • Pfeiffer Disease
Mature B-Cell Neoplasm

  • Mature B-Cell Lymphocytic Neoplasm

  • Neoplasm Of Mature B-Cells

  • Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS10284 PDLIM7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus PDLIM7 MGD MGI:1914649
Bos taurus PDLIM7 VGNC VGNC:32712
Felis catus PDLIM7 VGNC VGNC:64093
Macaca mulatta PDLIM7 VGNC VGNC:75848
Rattus norvegicus PDLIM7 RGD RGD:628769
Others PDLIM7 NCBI