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製品番号: HY-161408

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GePhos1

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

GePhos1, a EGFR-targeting PhosTAC (phosphorylation targeting chimera), induces EGFR dephosphorylation. GePhos1 induces apoptosis.

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純度: 98.88%
分子式: C₆₃H₇₅ClFN₇O₁₃
分子量:1192.76

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

GePhos1 構造式

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

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製品説明

GePhos1, a EGFR-targeting PhosTAC (phosphorylation targeting chimera), induces EGFR dephosphorylation. GePhos1 induces apoptosis^[1].

EGFR アイソフォーム固有の製品をすべて表示 :

体外実験

GePhos1 displays profound EGFR dephosphorylation at both EGFR pY1068, which is one of the major EGFR autophosphorylation sites, and at pY845, a key site within the kinase loop^[1].
GePhos1 (1 μM) induces apoptosis and cell death in HeLa cell^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

性状 Solid
分子量 1192.76
分子式 C₆₃H₇₅ClFN₇O₁₃
Color White to off-white
SMILES

COC1=C(OC)C=CC(CC[C@H](C2=CC(OCC(NCCC(N3CCN(CCCOC4=CC5=C(NC6=CC=C(F)C(Cl)=C6)N=CN=C5C=C4OC)CC3)=O)=O)=CC=C2)OC([C@@H]7CCCCN7C([C@@H](CC)C8=CC(OC)=C(OC)C(OC)=C8)=O)=O)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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2025 Mar 24.

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純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
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- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
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IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zhenyi Hu, et al. EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling. Sci Adv. 2024 Mar 29;10(13):eadj7251. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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GePhos1

1 Cited Publications

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Publications (1)
純度とドキュメンテーション
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GePhos1

Anti-Hepatitis C Virus Compound Library

Anti-Pancreatic Cancer Compound Library

Angiogenesis-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cell Death Library

Bioactive Compound Library Max

Bioactive Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Apoptosis Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

MedChemExpress（MCE）の使用を引用している文献 GePhos1

EGFR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

GePhos1

Anti-Hepatitis C Virus Compound Library

Anti-Pancreatic Cancer Compound Library

Angiogenesis-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cell Death Library

Bioactive Compound Library Max

Bioactive Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Apoptosis Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

MedChemExpress（MCE）の使用を引用している文献 GePhos1

EGFR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

GePhos1 関連分類

HY-161408 関連分類