Griffipavixanthone
Griffipavixanthone can be extracted from Garcinia schomburgkiana. Griffipavixanthone induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. Griffipavixanthone is an anti-cancer agent. Griffipavixanthone is a weak sucrase inhibitor (IC50: 4.58 mM).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 219649-95-3
- 分子式: C36H28O12
- 分子量:652.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
>10 μM
Compound: 16
|
Cytotoxicity against human HepG2 cells by MTT assay
Cytotoxicity against human HepG2 cells by MTT assay
|
[PMID: 24960143] |
| L02 | IC50 |
>10 μM
Compound: 16
|
Cytotoxicity against human HL7702 cells by MTT assay
Cytotoxicity against human HL7702 cells by MTT assay
|
[PMID: 24960143] |
| MCF7 | IC50 |
>10 μM
Compound: 16
|
Cytotoxicity against human MCF7 cells by MTT assay
Cytotoxicity against human MCF7 cells by MTT assay
|
[PMID: 24960143] |
| MDA-MB-231 | IC50 |
>10 μM
Compound: 16
|
Cytotoxicity against human MDA-MB-231 cells by MTT assay
Cytotoxicity against human MDA-MB-231 cells by MTT assay
|
[PMID: 24960143] |
化学情報
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CAS 番号 219649-95-3
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分子量 652.60
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分子式 C36H28O12
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SMILES
OC1=C(O)C(OC2=CC(O)=CC(O)=C2C3=O)=C3C4=C1[C@@H](C5=C6C(OC7=CC(O)=CC(O)=C7C6=O)=C(C(O)=C5)O)[C@@]8([H])[C@]4([H])C=C(C)CC8(C)C
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別名
(+)-Griffipavixanthone
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Lien Do TM, et al. Schomburgkixanthone, a novel bixanthone from the twigs of Garcinia schomburgkiana. Nat Prod Res. 2021 Nov;35(21):3613-3618. [Content Brief]
[2]. Shi JM, et al. Griffipavixanthone from Garcinia oblongifolia champ induces cell apoptosis in human non-small-cell lung cancer H520 cells in vitro. Molecules. 2014 Jan 27;19(2):1422-31. [Content Brief]
[3]. Ma Y, et al. Griffipavixanthone induces apoptosis of human breast cancer MCF-7 cells in vitro. Breast Cancer. 2019 Mar;26(2):190-197. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)