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製品番号: HY-119151

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GS-9191

GS-9191 is the prodrug of the nucleotide analog PMEG. GS-9191 is a topical agent to permeate skin and be metabolized to the active nucleoside triphosphate analog in the epithelial layer. GS-9191 inhibits NA synthesis, arrests cell in S phase, and induces cell apoptosis. GS-9191 can be used for research of human papillomaviruses (HPV) infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 859209-84-0
分子式: C₃₇H₅₁N₈O₆P
分子量:734.82

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

GS-9191 構造式

CAS 番号: 859209-84-0

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
Ca-Ski	EC₅₀	2.03 nM Compound: GS-9191	Antiproliferative activity against HPV-transformed human CaSki cells after 7 days by SRB assay Antiproliferative activity against HPV-transformed human CaSki cells after 7 days by SRB assay	[PMID: 19398642]
HeLa	EC₅₀	0.71 nM Compound: GS-9191	Antiproliferative activity against HPV-transformed human HeLa cells after 7 days by SRB assay Antiproliferative activity against HPV-transformed human HeLa cells after 7 days by SRB assay	[PMID: 19398642]
HT-3	EC₅₀	5.42 nM Compound: GS-9191	Antiproliferative activity against HPV-non-transformed human HT3 cells after 7 days by SRB assay Antiproliferative activity against HPV-non-transformed human HT3 cells after 7 days by SRB assay	[PMID: 19398642]
ME-180	EC₅₀	1.83 nM Compound: GS-9191	Antiproliferative activity against HPV-transformed human ME180 cells after 7 days by SRB assay Antiproliferative activity against HPV-transformed human ME180 cells after 7 days by SRB assay	[PMID: 19398642]
SCC-4	EC₅₀	5.03 nM Compound: GS-9191	Antiproliferative activity against HPV-non-transformed human SCC4 cells after 7 days by SRB assay Antiproliferative activity against HPV-non-transformed human SCC4 cells after 7 days by SRB assay	[PMID: 19398642]
SCC-9	EC₅₀	15.3 nM Compound: GS-9191	Antiproliferative activity against HPV-non-transformed human SCC9 cells after 7 days by SRB assay Antiproliferative activity against HPV-non-transformed human SCC9 cells after 7 days by SRB assay	[PMID: 19398642]
SiHa	EC₅₀	>74 nM Compound: GS-9191	Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 3 hrs by ELISA Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 3 hrs by ELISA	[PMID: 19398642]
SiHa	EC₅₀	0.03 nM Compound: GS-9191	Antiproliferative activity against HPV-transformed human SiHa cells after 7 days by SRB assay Antiproliferative activity against HPV-transformed human SiHa cells after 7 days by SRB assay	[PMID: 19398642]
SiHa	EC₅₀	1 nM Compound: GS-9191	Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 6 to 9 hrs by ELISA Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 6 to 9 hrs by ELISA	[PMID: 19398642]
SiHa	EC₅₀	1.8 nM Compound: GS-9191	Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 24 to 27 hrs by ELISA Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 24 to 27 hrs by ELISA	[PMID: 19398642]
SiHa	EC₅₀	11.5 nM Compound: GS-9191	Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 72 to 75 hrs by ELISA Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 72 to 75 hrs by ELISA	[PMID: 19398642]
SiHa	EC₅₀	7.8 nM Compound: GS-9191	Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 3 to 6 hrs by ELISA Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 3 to 6 hrs by ELISA	[PMID: 19398642]
SiHa	EC₅₀	7.9 nM Compound: GS-9191	Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 48 to 51 hrs by ELISA Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 48 to 51 hrs by ELISA	[PMID: 19398642]

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 859209-84-0
分子量 734.82
分子式 C₃₇H₅₁N₈O₆P
SMILES

CC(C)COC([C@H](CC1=CC=CC=C1)NP(COCCN2C3=NC(N)=NC(NC4CC4)=C3N=C2)(N[C@H](C(OCC(C)C)=O)CC5=CC=CC=C5)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wolfgang GH, et al. GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. Antimicrob Agents Chemother. 2009 Jul;53(7):2777-84. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- 臨床実験
化学情報
純度とドキュメンテーション
参考文献

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GS-9191

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

GS-9191 関連分類

HY-119151 関連分類