GSK990
GSK990 is an inactive mutant IDH1 inhibitor with no significant inhibitory activity against wild-type or mutant IDH1/IDH2 enzymes. In experiments, GSK990 can serve as an inactive negative control for the IDH1 inhibitor GSK321 (HY-18948). GSK990 is applicable to the research of acute myeloid leukemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1816331-64-2
- 分子式: C23H23N7O2
- 分子量:429.47
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
IDH1 |
体外実験
GSK990 acts as a weak inhibitor of mutant IDH1 enzymes (R132H, R132C, R132G) with IC50 values ranging from 4,495 to 23,255 nM, and shows no inhibitory activity against wild-type IDH1 or any IDH2 variants[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1816331-64-2
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分子量 429.47
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分子式 C23H23N7O2
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SMILES
O=C(NC1=CC=CC(C)=C1)C2=NN(C3=C2CN(CC3)C(C4=CC=CN4)=O)CC5=CNC=N5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GSK990 関連分類
HY-123153 関連分類
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