Hericenone C
Based on 1 Customer Validation
Hericenone C is a metabolite derived from Hericium erinaceus. Hericenone C inhibits LPS (HY-D1056)-induced NRE::Luc luciferase activity, reduces phosphorylation of p65 and inhibits NF-κB signaling. Hericenone C exhibits neuroprotective effect.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.07%
- CAS 番号: 137592-03-1
- 分子式: C35H54O6
- 分子量:570.80
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Hericenone C (2.5-20 μM, 1 h) inhibits luciferase activity and reduces p-P65 levels in LPS (HY-D1056)-induced NIH3T3 cells expressing NRE::Luc[1].
Hericenone C (40 μM, 1 h) inhibits the Formalin-induced increase in IL-6 mRNA expression and reduces the percentage of CD11c-positive cells in RAW264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Formalin-induced nociceptive model of male ICR mice[1]
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Dosage:2.5, 5 and 10 mg/kg
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Administration:Intraperitoneally injection, 45 mins before formalin
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Result:Reduced licking/biting timeof the second phase (10-45 min).
Showed no significant effect on the first phase (0-10 min).
Reduced the accumulation of CD11c-positive cells in the paw epidermis and inhibited the activation of p-P65 in CD11c-positive cells.
化学情報
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CAS 番号 137592-03-1
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性状 Solid
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分子量 570.80
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分子式 C35H54O6
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Color White to off-white
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SMILES
C/C(C)=C\C(C/C(C)=C/CC1=C(C=C(C(C=O)=C1O)COC(CCCCCCCCCCCCCCC)=O)OC)=O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外:
Ethanol : 50 mg/mL (87.60 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 1.7519 mL | 8.7596 mL | 17.5193 mL | 43.7982 mL |
| 5 mM | 0.3504 mL | 1.7519 mL | 3.5039 mL | 8.7596 mL | |
| 10 mM | 0.1752 mL | 0.8760 mL | 1.7519 mL | 4.3798 mL | |
| 15 mM | 0.1168 mL | 0.5840 mL | 1.1680 mL | 2.9199 mL | |
| 20 mM | 0.0876 mL | 0.4380 mL | 0.8760 mL | 2.1899 mL | |
| 25 mM | 0.0701 mL | 0.3504 mL | 0.7008 mL | 1.7519 mL | |
| 30 mM | 0.0584 mL | 0.2920 mL | 0.5840 mL | 1.4599 mL | |
| 40 mM | 0.0438 mL | 0.2190 mL | 0.4380 mL | 1.0950 mL | |
| 50 mM | 0.0350 mL | 0.1752 mL | 0.3504 mL | 0.8760 mL | |
| 60 mM | 0.0292 mL | 0.1460 mL | 0.2920 mL | 0.7300 mL | |
| 80 mM | 0.0219 mL | 0.1095 mL | 0.2190 mL | 0.5475 mL |
Hericenone C 関連分類
HY-N16500 関連分類
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