HPMC (Viscosity:11250-21000mPa.s)
Based on 3 publication(s) in Google Scholar
HPMC (Viscosity:11250-21000mPa.s) is a hydrophilic, non-ionic cellulose ether used to form swellable-soluble matrices.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 9004-65-3
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 HPMC (Viscosity:11250-21000mPa.s)
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生物活性
Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong its therapeutic effect[1]. Hypromellose (hydroxypropylmethylcellulose) has been used in sustained-release pharmaceutical products for many years. When used in matrix tablets, these polymers hydrate on contact with water to produce a viscous gel barrier within and surrounding the tablet. The properties of hypromellose that affect the rate of drug release include the rate of diffusion of water into the dry polymer, the rate of hypromellose hydration and gel formation, the viscosity of the hydrated hypromellose and rate of hypromellose gel erosion[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 9004-65-3
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性状 Solid
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Color White to off-white
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SMILES
[R]O[C@@H]1[C@H](O[R])[C@@H](O[R])[C@H](O[C@H]2[C@H](O[R])[C@@H](O[R])[C@H](O[R])[C@@H](CO[R])O2)[C@@H](CO[R])O1.CO.CC(O)CO.[n].[x]
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別名
Hypromellose (Viscosity:11250-21000mPa.s); (Hydroxypropyl)methyl cellulose (Viscosity:11250-21000mPa.s); Celacol HPM 5000 (Viscosity:11250-21000mPa.s)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Cancer Cell
Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. [Abstract]2021 Mar 8;39(3):423-437.e7. PMID: 33450198 -
Nat Commun
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy. [Abstract]2023 May 19;14(1):2859. PMID: 37208329 -
Oncogene
2022 May;41(22):3064-3078. PMID: 35461328
溶剤 & 溶解度
DMSO : 25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 10 mg/mL (Need ultrasonic)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 8.33 mg/mL; Clear solution; Need ultrasonic and warming and heat to 60°C
純度とドキュメンテーション
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データシート (274 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Li CL, et al. The use of hypromellose in oral drug delivery. J Pharm Pharmacol. 2005 May;57(5):533-46. [Content Brief]
[2]. Braund R, et al. Hypromellose films for the delivery of growth factors for wound healing. [Content Brief]
[3]. Capita L, et al. Prospective evaluation of hypromellose 2% for punctal occlusion in patients with dry eye. Cornea. 2015 Feb;34(2):188-92. [Content Brief]
[4]. Ban SJ, et al. Antihyperglycemic and antioxidative effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in mice fed with a high fat diet. Int J Mol Sci. 2012;13(3):3738-50. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
HPMC (Viscosity:11250-21000mPa.s) 関連分類
HY-A0104 関連分類
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