HS38
Based on 3 publication(s) in Google Scholar
HS38 is a potent, selective, and ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) and zipper-interacting protein kinase (ZIPK, also called DAPK3), with Kds of 300 nM and 280 nM, respectively. HS38 is also a PIM3 inhibitor with an IC50 of 200 nM. HS38 can be used for the research of smooth muscle related disorders.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.91%
- CAS 番号: 1030203-81-6
- 分子式: C14H12ClN5O2S
- 分子量:349.80
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 HS38
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生物活性
Kd: 300 nM (DAPK1), 79 nM (DAPK2), 280 nM (ZIPK), IC50: 200 nM (DAPK1), 200 nM (PIM3)[1]
HS38 displays high affinity toward DAPK2, with a Kd of 79 nM. DAPK2 is not implicated in smooth muscle contractility[1].
HS38 significantly reduces relative RLC20 phosphorylation in both the basal and sphingosine 1-phosphate (S1P) activated states in human aortic SM cells[1].
HS38 reduces contractile forces generated by intact mouse aorta in aortic tissue[1].
HS38 reduces the contractile force, RLC20 phosphorylation, and MYPT1 phosphorylation in Ca2+-sensitized rabbit ileum[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CA-VSMCs
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Concentration:10 µM
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Incubation Time:40 minutes
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Result:Reduced relative RLC20 phosphorylation in both the basal and S1P activated states.
化学情報
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CAS 番号 1030203-81-6
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性状 Solid
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分子量 349.80
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分子式 C14H12ClN5O2S
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Color White to off-white
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SMILES
CC(SC1=NC(N(C2=CC=CC(Cl)=C2)N=C3)=C3C(N1)=O)C(N)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Commun
Identification of splenic IRF7 as a nanotherapy target for tele-conditioning myocardial reperfusion injury. [Abstract]2025 Feb 24;16(1):1909. PMID: 39994192 -
Cell Death Dis
Zipper-interacting protein kinase mediates neuronal cell death and cognitive dysfunction in traumatic brain injury via regulating DEDD. [Abstract]2025 Mar 4;16(1):151. PMID: 40032841 -
Life Sci
Auto- and paracrine rewiring of NIX-mediated mitophagy by insulin-like growth factor-binding protein 7 in septic AKI escalates inflammation-coupling tubular damage. [Abstract]2023 Jun 1:322:121653. PMID: 37011875
溶剤 & 溶解度
DMSO : 7.14 mg/mL (20.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (393 KB)
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- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8588 mL | 14.2939 mL | 28.5878 mL | 71.4694 mL |
| 5 mM | 0.5718 mL | 2.8588 mL | 5.7176 mL | 14.2939 mL | |
| 10 mM | 0.2859 mL | 1.4294 mL | 2.8588 mL | 7.1469 mL | |
| 15 mM | 0.1906 mL | 0.9529 mL | 1.9059 mL | 4.7646 mL | |
| 20 mM | 0.1429 mL | 0.7147 mL | 1.4294 mL | 3.5735 mL |
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