HX600
Based on 1 Customer Validation
HX600 is a synthetic agonist for RXR (Retinoid X Receptor) heterodimer complex. HX600 prevents ischemia-induced neuronal damage. HX600 has orally bioactivity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.4%
- CAS 番号: 172705-89-4
- 分子式: C29H30N2O2
- 分子量:438.56
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Multi-Target Compound Library
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Metabolism/Protease Compound Library
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生物活性
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RXR α 1.9 μM (Ki) |
RXR β 0.64 μM (Ki) |
RXR γ 1 μM (Ki) |
HX600 (100-1000 μM; 24 h) is not directly neuroprotective against glutamate exposure[1].
HX600 (1 μM; 24 h) inhibits the expression of inflammatory mediators in primary microglia and prevents inflammation induced neuronal death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary Cortical Neuron Cells
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Concentration:0 μM, 0.1 μM, 0.2 μM, 0.5 μM, 1 μM, 2 μM, 5 μM, 10 μM, 20 μM
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Incubation Time:24 h
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Result:Showd HX600 was not able to prevent the glutamate induced neuronal death.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ischemic Mice[1]
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Dosage:60 mg/kg
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Administration:Oral Gavage (p.o.)
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Result:Revealed that mice treated with HX600 had smaller lesion with the size of 21%, and significantly reduction in Iba-1, phospho-p38 and TREM-2 at protein level.
化学情報
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CAS 番号 172705-89-4
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性状 Solid
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分子量 438.56
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分子式 C29H30N2O2
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Color Yellow to orange
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SMILES
O=C(O)C1=CC=C(C2=NC3=CC=CC=C3N(C)C4=CC5=C(C(C)(C)CCC5(C)C)C=C42)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (281 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Siddhesh S Kamat, et al. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nat Chem Biol 2015 Feb;11(2):164-71. [Content Brief]
[2]. Hiroki Umemiya, et al. Action Mechanism of Retinoid-Synergistic Dibenzodiazepines. Biochem Biophys Res Commun. 1997 Apr 7;233(1):121-5. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
HX600 関連分類
HY-120875 関連分類
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