製品番号: HY-121204

Iberverin

(別名: 3-Methylthiopropyl isothiocyanate)

カスタマーレビュー

Based on 1 Customer Validation

Iberverin (-Methylthiopropyl isothiocyanate) is a sulforaphane homolog. Iberverin has anticancer activity. Iberverin inhibits cell proliferation and migration. Iberverin induces mitochondrial-related apoptosis and intracellular reactive oxygen species.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 98.0%
CAS 番号: 505-79-3
分子式: C₅H₉NS₂
分子量:147.26

保管条件:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Iberverin 構造式

CAS 番号: 505-79-3

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Iberverin (0-200 μM, 48 h) inhibits the viability and proliferation of HCC cells, with IC₅₀s less than 25 μM for Huh7, Huh7.5.1, and SNU739^[1].
Iberverin (10 μM, 24-72 h) inhibits migration and invasion in Huh7, Huh7.5.1 and SNU739 cells^[1].
Iberverin (40 μM, 12 h) induces mitochondrial-related apoptosis, induces DNA damage and causes G2/M cell cycle arrest in Huh7, Huh7.5.1 and SNU739 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Huh7, Huh7.5.1 and SNU739 cells
Concentration:

40 μM
Incubation Time:

12 h
Result:

Enhanced the level of apoptotic protein Bax but repressed the expression of Bcl-2.

体内実験

Iberverin (20 mg/kg, i.p., every 3 days for five cycles) inhibits the growth of HCC xenograft tumor in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Huh7.5.1 cells were subcutaneously injected into immunodeficient BALB/c nude mice^[1]
Dosage:

20 mg/kg
Administration:

i.p., every 3 days for five cycles
Result:

Reduction the tumor size by 73.4% and weight by 55.3% of Huh7.5.1 xenograft tumors, with no systematic toxicity.
Decreased Ki-67 and PCNA level in tumor.

化学情報

CAS 番号 505-79-3
性状 Liquid (Density: 1.05±0.1 g/cm³)
分子量 147.26
分子式 C₅H₉NS₂
Color Colorless to light yellow
SMILES

CSCCCN=C=S
別名

3-Methylthiopropyl isothiocyanate
Structure Classification
- Others
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (679.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.7907 mL

33.9536 mL

67.9071 mL

5 mM

1.3581 mL

6.7907 mL

13.5814 mL

10 mM

0.6791 mL

3.3954 mL

6.7907 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
SDS (627 KB)
- English - EN (627 KB)
- Français - FR (627 KB)
- Deutsch - DE (627 KB)
- Norwegian - NO (627 KB)
- Español - ES (627 KB)
- Swedish - SV (627 KB)
- Italian - IT (627 KB)
- Korean - KR (627 KB)
- Portuguese - PT (627 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. 1. Zhang Y, et al. Iberverin exhibits antineoplastic activities against human hepatocellular carcinoma via DNA damage-mediated cell cycle arrest and mitochondrial-related apoptosis. Front Pharmacol. 2023 Dec 13;14:1326346. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.7907 mL	33.9536 mL	67.9071 mL	169.7678 mL
	5 mM	1.3581 mL	6.7907 mL	13.5814 mL	33.9536 mL
	10 mM	0.6791 mL	3.3954 mL	6.7907 mL	16.9768 mL
	15 mM	0.4527 mL	2.2636 mL	4.5271 mL	11.3179 mL
	20 mM	0.3395 mL	1.6977 mL	3.3954 mL	8.4884 mL
	25 mM	0.2716 mL	1.3581 mL	2.7163 mL	6.7907 mL
	30 mM	0.2264 mL	1.1318 mL	2.2636 mL	5.6589 mL
	40 mM	0.1698 mL	0.8488 mL	1.6977 mL	4.2442 mL
	50 mM	0.1358 mL	0.6791 mL	1.3581 mL	3.3954 mL
	60 mM	0.1132 mL	0.5659 mL	1.1318 mL	2.8295 mL
	80 mM	0.0849 mL	0.4244 mL	0.8488 mL	2.1221 mL
	100 mM	0.0679 mL	0.3395 mL	0.6791 mL	1.6977 mL

Keywords

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

Iberverin

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Natural Product Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Medicine Food Homology Compound Library

Traditional Chinese Medicine Active Compound Library

Food Additive Library

Food-Sourced Compound Library

Anti-Cancer Natural Product Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Cysteine Targeted Covalent Fragment Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Flavor Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Metabolite Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Flavors and Fragrances Compound Library

Natural Product Diversity Scaffold Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Iberverin 関連分類

HY-121204 関連分類