Isatin-O
Isatin-O (Isatin β-oxime; Isatin 3-oxime) is an acetylcholinesterase (AChE) reactivator capable of crossing the blood-brain barrier. Isatin-O reactivates paraoxon-inhibited acetylcholinesterase in the central and peripheral nervous systems. As a glycosylation substrate, Isatin-O undergoes complete glycosylation in a Rauvolfia serpentina cell suspension culture system to form isatin-3-oxime-glucoside. Isatin-O can be used in studies related to organophosphate poisoning.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 607-28-3
- 分子式: C8H6N2O2
- 分子量:162.15
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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AChE |
Isatin-O (10-100 μmol/L; 10-120 min) reactivates paraoxon-inhibited Electrophorus electricus acetylcholinesterase, reaching ~8% reactivation at 10 μmol/L within 10 min and ~23% reactivation at 100 μmol/L after 120 min, with better initial reactivation performance than 2-PAM at 10 μmol/L[1].
Isatin-O (5.76 mM; 72 h) is completely glucosylated by Rauvolfia serpentina plant cell suspension cultures to form Isatin-3-oxime-β-D-glucopyranoside within 72 h, with the glucoside accumulating intracellularly without further metabolism[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 607-28-3
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分子量 162.15
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分子式 C8H6N2O2
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SMILES
O=C1NC=2C=CC=CC2C1=NO
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別名
Isatin β-oxime; Isatin 3-oxime
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. de Paula RL, et al. Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon. Molecules (Basel, Switzerland). 2018 Nov 12;23(11):2954. [Content Brief]
[2]. Hinse C, et al. Glucosylation of isatin-3-oxime followed by 2D in situ NMR in plant cells at highest magnetic field without labelling. Natural product letters. 2001;15(2):119-24. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Isatin-O 関連分類
HY-115841 関連分類
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- Isatin-O
- 607-28-3
- Isatin β-oxime
- Isatin 3-oxime
- Cholinesterase (ChE)
- peripheral nervous systems
- acetylcholinesterase
- isatin-3-oxime-glucoside
- blood-brain barrier
- glucosylation substrate
- Electrophorus electricus acetylcholinesterase
- paraoxon-inhibited acetylcholinesterase
- Rauvolfia serpentina cell suspension cultures
- organophosphate poisoning
- central nervous systems
- Inhibitor
- inhibitor
- inhibit