IVHD-valtrate
IVHD-valtrate, an active Valeriana jatamansi derivative, is against human ovarian cancer cells in vitro and in vivo. IVHD-valtrate induces cancer cells apoptosis and arrests the ovarian cancer cells in the G2/M phase. IVHD-valtrate has the potential to be a novel chemotherapeutic agent for the human ovarian cancer research.
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- CAS 番号: 28325-56-6
- 分子式: C27H40O11
- 分子量:540.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
IC50: apoptosis[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
7.4 μM
Compound: 18
|
Cytotoxicity against human A549 cells after 24 hrs by MTT assay
Cytotoxicity against human A549 cells after 24 hrs by MTT assay
|
[PMID: 19245261] |
| Bel-7402 | IC50 |
4 μM
Compound: 18
|
Cytotoxicity against human Bel7402 cells after 24 hrs by MTT assay
Cytotoxicity against human Bel7402 cells after 24 hrs by MTT assay
|
[PMID: 19245261] |
| HCT-8 | IC50 |
2.5 μM
Compound: 18
|
Cytotoxicity against human HCT8 cells after 24 hrs by MTT assay
Cytotoxicity against human HCT8 cells after 24 hrs by MTT assay
|
[PMID: 19245261] |
| PC-3M | IC50 |
1.9 μM
Compound: 18
|
Cytotoxicity against human PC3M cells after 24 hrs by MTT assay
Cytotoxicity against human PC3M cells after 24 hrs by MTT assay
|
[PMID: 19245261] |
IVHD-valtrate inhibits the growth and proliferation of the A2780 and OVCAR-3 ovarian cancer cell lines in a concentration-dependent manner[1].IVHD-valtrate results in a relatively low cytotoxicity to immortalized non-tumorigenic human ovarian surface epithelial cells (IOSE-144)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 28325-56-6
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分子量 540.60
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分子式 C27H40O11
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SMILES
CC(O[C@@H](C1)[C@]2(CO2)[C@]([C@@H]3OC(CC(C)C)=O)([H])[C@]1(C(COC(C(C(C)C)OC(CC(C)C)=O)=O)=CO3)O)=O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)