Izumerogant
Based on 1 Customer Validation
Izumerogant (IMU-935) is an orally active RORγ/DHODH dual inhibitor with IC50s of 10 and 98 nM against RORγ and DHODH. Izumerogant efficiently blocks the replication of SARS-CoV-2, HCMV and HAdV5 with EC50 values between 3.6 and 17 nM. Izumerogant can be used for researching antiviral properties.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.95%
- CAS 番号: 2299252-72-3
- 分子式: C22H18ClF4N5O2
- 分子量:495.86
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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RORγ 10 nM (IC50) |
Izumerogant exhibits nanomolar inhibitory activity against SARS-CoV-2, HCMV and HAdV5 with EC50s of 3.6 nM, 17 nM and 12 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 2299252-72-3
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性状 Solid
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分子量 495.86
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分子式 C22H18ClF4N5O2
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Color Off-white to light brown
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SMILES
FC1=CC=CC(Cl)=C1C2=NOC(C3=C(C(F)(F)F)N(CCC(C)(C)O)N=C3)=C2C4=NC=CC=N4
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別名
IMU-935
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 200 mg/mL (403.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
[2]. Polasek TM, et al. Safety, Tolerability, and Pharmacokinetics of IMU-935, a Novel Inverse Agonist of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γt: Results From a Double-Blind, Placebo-Controlled, First-in-Human Phase 1 Study. Clin Pharmacol Drug Dev. 2023 May;12(5):525-534. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0167 mL | 10.0835 mL | 20.1670 mL | 50.4175 mL |
| 5 mM | 0.4033 mL | 2.0167 mL | 4.0334 mL | 10.0835 mL | |
| 10 mM | 0.2017 mL | 1.0083 mL | 2.0167 mL | 5.0417 mL | |
| 15 mM | 0.1344 mL | 0.6722 mL | 1.3445 mL | 3.3612 mL | |
| 20 mM | 0.1008 mL | 0.5042 mL | 1.0083 mL | 2.5209 mL | |
| 25 mM | 0.0807 mL | 0.4033 mL | 0.8067 mL | 2.0167 mL | |
| 30 mM | 0.0672 mL | 0.3361 mL | 0.6722 mL | 1.6806 mL | |
| 40 mM | 0.0504 mL | 0.2521 mL | 0.5042 mL | 1.2604 mL | |
| 50 mM | 0.0403 mL | 0.2017 mL | 0.4033 mL | 1.0083 mL | |
| 60 mM | 0.0336 mL | 0.1681 mL | 0.3361 mL | 0.8403 mL | |
| 80 mM | 0.0252 mL | 0.1260 mL | 0.2521 mL | 0.6302 mL | |
| 100 mM | 0.0202 mL | 0.1008 mL | 0.2017 mL | 0.5042 mL |
Izumerogant 関連分類
HY-152851 関連分類
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